TY  - JOUR
AU  - Borràs, Emma
AU  - Jurado, Ismael
AU  - Hernan, Imma
AU  - Gamundi, María José
AU  - Dias, Miguel
AU  - Martí, Isabel
AU  - Mañé, Begoña
AU  - Arcusa, Àngels
AU  - Agúndez, José AG
AU  - Blanca, Miguel
AU  - Carballo, Miguel
PY  - 2011
DO  - 10.1186/1471-2407-11-406
UR  - http://hdl.handle.net/10668/362
T2  - BioMed Central
AB  - BACKGROUND: Epidermal growth factor receptor (EGFR) and its downstream factors KRAS and BRAF are mutated in several types of cancer, affecting the clinical response to EGFR inhibitors. Mutations in the EGFR kinase domain predict sensitivity to the...
LA  - en
PB  - BioMed Central
KW  - Neoplasias
KW  - Secuencia de Bases
KW  - Análisis Mutacional de ADN
KW  - Terapia Molecular Dirigida
KW  - Factores Biológicos
KW  - Alineación de Secuencia
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing
KW  - Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted Therapy
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::MAP Kinase Kinase Kinases::raf...
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Peptide::Receptors, Growth Factor::Receptor, Epidermal Growth Factor
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Reproducibility of Results
KW  - Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Sensitivity and Specificity
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Alignment
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Monomeric GTP-Binding Proteins::ras Proteins
TI  - Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing
TY  - research article
ER  -