%0 Journal Article
%A Gutierrez-Valencia, Alicia
%A Benmarzouk-Hidalgo, Omar J
%A Llaves, Silvia
%A Fernandez-Magdaleno, Tamara
%A Espinosa, Nuria
%A Viciana, Pompeyo
%A Lopez-Cortes, Luis F
%T Pharmacokinetic interactions between cobicistat-boosted elvitegravir and darunavir in HIV-infected patients.
%D 2017
%U http://hdl.handle.net/10668/10699
%X Objectives: To evaluate if there are significant drug – drug interactions between cobicistat -boosted elvitegravir and 800 mg darunavir once daily taken simultaneously, as has been suggested previously. Methods : The study population consisted of three groups of unselected volunteers taking a regimen of elvitegravir, cobicistat , emtricitabine and tenofovir disoproxil fumarate (150, 150, 200 and 300 mg, respectively) co-formulated in a single tablet plus 800 mg darunavir (group A); only co-formulated elvitegravir, cobicistat , emtricitabine and tenofovir disoproxil fumarate (group B); and cobicistat -boosted darunavir (800 mg darunavir  + 150 mg cobicistat ) plus two nucleos(t)ide analogues (group C). Elvitegravir, cobicistat and darunavir concentrations at the end of the dosing interval (C24) were quantified using a validated LC with tandem MS method .Results: A total of 170 samples were obtained from 24, 32 and 32 patients in groups A, B and C, respectively. In group A, the elvitegravir C24 were similar to those in group B (233.67 versus 250.39 ng/mL) (P = 0.406) and the darunavir  C24 were similar to those in group C (1293.54 versus 1319.34 ng/mL) (P = 0.908). The cobicistat  C24 were comparable in groups A and B (20.2 versus 20.9 ng/mL) and slightly higher in group C (27.7 ng/mL) (P = 0.059).Conclusions: The results provide evidence of similar elvitegravir and darunavir  C24 concentrations when these drugs are co-administered as co-formulated elvitegravir, cobicistat , emtricitabine and tenofovir disoproxil fumarate plus 800 mg darunavir or dosed separately.
%K Anti-HIV Agents
%K Drug Combinations
%K HIV Infections
%K Male
%K Young Adult
%~