RT Journal Article
T1 The Parkinson's Disease Mendelian Randomization Research Portal.
A1 Noyce, Alastair J
A1 Bandres-Ciga, Sara
A1 Kim, Jonggeol
A1 Heilbron, Karl
A1 Kia, Demis
A1 Hemani, Gibran
A1 Xue, Angli
A1 Lawlor, Debbie A
A1 Smith, George Davey
A1 Duran, Raquel
A1 Gan-Or, Ziv
A1 Blauwendraat, Cornelis
A1 Gibbs, J Raphael
A1 Hinds, David A
A1 Yang, Jian
A1 Visscher, Peter
A1 Cuzick, Jack
A1 Morris, Huw
A1 Hardy, John
A1 Wood, Nicholas W
A1 Nalls, Mike A
A1 Singleton, Andrew B
K1 Mendelian randomization
K1 Parkinson's disease
K1 public resource
K1 risk factor
AB Mendelian randomization is a method for exploring observational associations to find evidence of causality. To apply Mendelian randomization between risk factors/phenotypic traits (exposures) and PD in a large, unbiased manner, and to create a public resource for research. We used two-sample Mendelian randomization in which the summary statistics relating to single-nucleotide polymorphisms from 5,839 genome-wide association studies of exposures were used to assess causal relationships with PD. We selected the highest-quality exposure genome-wide association studies for this report (n = 401). For the disease outcome, summary statistics from the largest published PD genome-wide association studies were used. For each exposure, the causal effect on PD was assessed using the inverse variance weighted method, followed by a range of sensitivity analyses. We used a false discovery rate of 5% from the inverse variance weighted analysis to prioritize exposures of interest. We observed evidence for causal associations between 12 exposures and risk of PD. Of these, nine were effects related to increasing adiposity and decreasing risk of PD. The remaining top three exposures that affected PD risk were tea drinking, time spent watching television, and forced vital capacity, but these may have been biased and were less convincing. Other exposures at nominal statistical significance included inverse effects of smoking and alcohol. We present a new platform which offers Mendelian randomization analyses for a total of 5,839 genome-wide association studies versus the largest PD genome-wide association studies available (https://pdgenetics.shinyapps.io/MRportal/). Alongside, we report further evidence to support a causal role for adiposity on lowering the risk of PD. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
PB John Wiley & Sons, Inc.
YR 2019
FD 2019-08-05
LK http://hdl.handle.net/10668/15488
UL http://hdl.handle.net/10668/15488
LA en
NO Noyce AJ, Bandres-Ciga S, Kim J, Heilbron K, Kia D, Hemani G, et al. The Parkinson's Disease Mendelian Randomization Research Portal. Mov Disord. 2019 Dec;34(12):1864-1872.
DS RISalud
RD Apr 6, 2025