TY - JOUR AU - Sánchez-Ceinos, Julia AU - Guzmán-Ruiz, Rocío AU - Rangel-Zúñiga, Oriol Alberto AU - López-Alcalá, Jaime AU - Moreno-Caño, Elena AU - Del Río-Moreno, Mercedes AU - Romero-Cabrera, Juan Luis AU - Pérez-Martínez, Pablo AU - Maymo-Masip, Elsa AU - Vendrell, Joan AU - Fernández-Veledo, Sonia AU - Fernández-Real, José Manuel AU - Laurencikiene, Jurga AU - Rydén, Mikael AU - Membrives, Antonio AU - Luque, Raul M AU - López-Miranda, José AU - Malagón, María M PY - 2021 DO - 10.7554/eLife.65996 UR - https://hdl.handle.net/10668/27857 T2 - eLife AB - Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the... LA - en KW - ER-proteostasis KW - ERAD KW - RNA splicing KW - UPR KW - cell biology KW - human KW - obesity-related metabolic diseases KW - preadipocytes KW - Adipocytes KW - Adipogenesis KW - Adult KW - Cell Differentiation KW - Cell Line KW - Diabetes Mellitus, Type 2 KW - Female KW - Humans KW - Male KW - Middle Aged KW - Obesity KW - Proteostasis KW - RNA, Messenger TI - Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease. TY - research article VL - 10 ER -