%0 Journal Article
%A van Gelder, M
%A de Wreede, L C
%A Bornhäuser, M
%A Niederwieser, D
%A Karas, M
%A Anderson, N S
%A Gramatzki, M
%A Dreger, P
%A Michallet, M
%A Petersen, E
%A Bunjes, D
%A Potter, M
%A Beelen, D
%A Cornelissen, J J
%A Yakoub-Agha, I
%A Russell, N H
%A Finke, J
%A Schoemans, H
%A Vitek, A
%A Urbano-Ispízua, Á
%A Blaise, D
%A Volin, L
%A Chevallier, P
%A Caballero, D
%A Putter, H
%A van Biezen, A
%A Henseler, A
%A Schönland, S
%A Kröger, N
%A Schetelig, J
%T Long-term survival of patients with CLL after allogeneic transplantation: a report from the European Society for Blood and Marrow Transplantation.
%D 2016
%U https://hdl.handle.net/10668/25107
%X Even with the availability of targeted drugs, allogeneic hematopoietic cell transplantation (allo-HCT) is the only therapy with curative potential for patients with CLL. Cure can be assessed by comparing long-term survival of patients to the matched general population. Using data from 2589 patients who received allo-HCT between 2000 and 2010, we used landmark analyses and methods from relative survival analysis to calculate excess mortality compared with an age-, sex- and calendar year-matched general population. Estimated event-free survival, overall survival and non-relapse mortality (NRM) 10 years after allo-HCT were 28% (95% confidence interval (CI), 25-31), 35% (95% CI, 32-38) and 40% (95% CI, 37-42), respectively. Patients who passed the 5-year landmark event-free survival (N=394) had a 79% probability (95% CI, 73-85) of surviving the subsequent 5 years without an event. Relapse and NRM contributed equally to treatment failure. Five-year mortality for 45- and 65-year-old reference patients who were event-free at the 5-year landmark was 8% and 47% compared with 3% and 14% in the matched general population, respectively. The prospect of long-term disease-free survival remains an argument to consider allo-HCT for young patients with high-risk CLL, and programs to understand and prevent late causes of failure for long-term survivors are warranted, especially for older patients.
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