RT Journal Article
T1 Cardiac troponin and COVID-19 severity: Results from BIOCOVID study.
A1 García de Guadiana-Romualdo, Luis
A1 Morell-García, Daniel
A1 Rodríguez-Fraga, Olaia
A1 Morales-Indiano, Cristian
A1 María Lourdes Padilla Jiménez, Ana
A1 Gutiérrez Revilla, José Ignacio
A1 Urrechaga, Eloísa
A1 Álamo, José María
A1 Hernando Holgado, Ana María
A1 Lorenzo-Lozano, María Del Carmen
A1 Sánchez Fdez-Pacheco, Silvia
A1 de la Hera Cagigal, Patricia
A1 Juncos Tobarra, María Ángeles
A1 Vílchez, Juan A
A1 Vírseda Chamorro, Isabel
A1 Gutiérrez Garcia, Irene
A1 Pastor Murcia, Yolanda
A1 Sahuquillo Frías, Laura
A1 Altimira Queral, Laura
A1 Nuez-Zaragoza, Elisa
A1 Adell Ruiz de León, Juan
A1 Ruiz Ripa, Alicia
A1 Salas Gómez-Pablos, Paloma
A1 Cebreiros López, Iria
A1 Fernández Uriarte, Amaia
A1 Larruzea, Álex
A1 López Yepes, María Luisa
A1 Sancho-Rodríguez, Natalia
A1 Zamorano Andrés, María Consuelo
A1 Pedregosa Díaz, José
A1 Acevedo Alcaraz, Cristina
A1 Blázquez Manzanera, Alfonso-L
A1 Pérez Sanmartín, Sonia
A1 Baamonde Calzada, María Del Carmen
A1 Vera, Marina
A1 Valera Nuñez, Elena
A1 Canalda Campás, Magdalena
A1 García Muñoz, Sara
A1 Bauça, Josep Miquel
A1 Vicente Gutiérrez, Luis
A1 Jiménez Añón, Laura
A1 Pérez Martínez, Alfonso
A1 Pons Castillo, Aurelio
A1 González Tamayo, Ruth
A1 Férriz Vivancos, Jorge
A1 José Alcaide Martín, María
A1 Ferrer Díaz de Brito Fernández, Vicente
A1 Aguadero, Vicente
A1 García Arévalo, María Gloria
A1 Arnaldos Carrillo, María
A1 González Morales, Mercedes
A1 Núñez Gárate, María
A1 Ruiz Iruela, Cristina
A1 Esteban Torrella, Patricia
A1 Vila Pérez, Martí
A1 Egea-Caparrós, Jose Manuel
A1 Sáenz, Luis
A1 Galán Ortega, Amparo
A1 Consuegra-Sánchez, Luciano
K1 COVID-19
K1 SARS-CoV-2
K1 cardiac troponin I
K1 cardiac troponin T
K1 myocardial injury
K1 prognosis
AB Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P  In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19.
YR 2021
FD 2021-03-15
LK http://hdl.handle.net/10668/17269
UL http://hdl.handle.net/10668/17269
LA en
DS RISalud
RD Jul 30, 2025