%0 Journal Article
%A García de Guadiana-Romualdo, Luis
%A Morell-García, Daniel
%A Rodríguez-Fraga, Olaia
%A Morales-Indiano, Cristian
%A María Lourdes Padilla Jiménez, Ana
%A Gutiérrez Revilla, José Ignacio
%A Urrechaga, Eloísa
%A Álamo, José María
%A Hernando Holgado, Ana María
%A Lorenzo-Lozano, María Del Carmen
%A Sánchez Fdez-Pacheco, Silvia
%A de la Hera Cagigal, Patricia
%A Juncos Tobarra, María Ángeles
%A Vílchez, Juan A
%A Vírseda Chamorro, Isabel
%A Gutiérrez Garcia, Irene
%A Pastor Murcia, Yolanda
%A Sahuquillo Frías, Laura
%A Altimira Queral, Laura
%A Nuez-Zaragoza, Elisa
%A Adell Ruiz de León, Juan
%A Ruiz Ripa, Alicia
%A Salas Gómez-Pablos, Paloma
%A Cebreiros López, Iria
%A Fernández Uriarte, Amaia
%A Larruzea, Álex
%A López Yepes, María Luisa
%A Sancho-Rodríguez, Natalia
%A Zamorano Andrés, María Consuelo
%A Pedregosa Díaz, José
%A Acevedo Alcaraz, Cristina
%A Blázquez Manzanera, Alfonso-L
%A Pérez Sanmartín, Sonia
%A Baamonde Calzada, María Del Carmen
%A Vera, Marina
%A Valera Nuñez, Elena
%A Canalda Campás, Magdalena
%A García Muñoz, Sara
%A Bauça, Josep Miquel
%A Vicente Gutiérrez, Luis
%A Jiménez Añón, Laura
%A Pérez Martínez, Alfonso
%A Pons Castillo, Aurelio
%A González Tamayo, Ruth
%A Férriz Vivancos, Jorge
%A José Alcaide Martín, María
%A Ferrer Díaz de Brito Fernández, Vicente
%A Aguadero, Vicente
%A García Arévalo, María Gloria
%A Arnaldos Carrillo, María
%A González Morales, Mercedes
%A Núñez Gárate, María
%A Ruiz Iruela, Cristina
%A Esteban Torrella, Patricia
%A Vila Pérez, Martí
%A Egea-Caparrós, Jose Manuel
%A Sáenz, Luis
%A Galán Ortega, Amparo
%A Consuegra-Sánchez, Luciano
%T Cardiac troponin and COVID-19 severity: Results from BIOCOVID study.
%D 2021
%U http://hdl.handle.net/10668/17269
%X Myocardial injury is a common finding in COVID-19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID-19 patients, and further evaluated separately the role of troponin T and I. This is a multicentre, retrospective observational study enrolling patients with laboratory-confirmed COVID-19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex-specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty-day mortality was defined as endpoint. A total of 1280 COVID-19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut-off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex-specific cut-off was used. This prevalence was significantly higher (42.9% vs 21.9%; P  In this multicentre study, myocardial injury was a common finding in COVID-19 patients. Its prevalence increased when a sex-specific cut-off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30-day mortality, irrespective of cardiac troponin assay and cut-offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID-19.
%K COVID-19
%K SARS-CoV-2
%K cardiac troponin I
%K cardiac troponin T
%K myocardial injury
%K prognosis
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