RT Journal Article
T1 Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.
A1 Merritt, Melissa A
A1 Tzoulaki, Ioanna
A1 van den Brandt, Piet A
A1 Schouten, Leo J
A1 Tsilidis, Konstantinos K
A1 Weiderpass, Elisabete
A1 Patel, Chirag J
A1 Tjønneland, Anne
A1 Hansen, Louise
A1 Overvad, Kim
A1 His, Mathilde
A1 Dartois, Laureen
A1 Boutron-Ruault, Marie-Christine
A1 Fortner, Renée T
A1 Kaaks, Rudolf
A1 Aleksandrova, Krasimira
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Bamia, Christina
A1 Palli, Domenico
A1 Krogh, Vittorio
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Mattiello, Amalia
A1 Bueno-de-Mesquita, H Bas
A1 Onland-Moret, N Charlotte
A1 Peeters, Petra H
A1 Skeie, Guri
A1 Jareid, Mie
A1 Quirós, J Ramón
A1 Obón-Santacana, Mireia
A1 Sanchez-Perez, Maria-Jose
A1 Chamosa, Saioa
A1 Huerta, José M
A1 Barricarte, Aurelio
A1 Dias, Joana A
A1 Sonestedt, Emily
A1 Idahl, Annika
A1 Lundin, Eva
A1 Wareham, Nicholas J
A1 Khaw, Kay-Tee
A1 Travis, Ruth C
A1 Ferrari, Pietro
A1 Riboli, Elio
A1 Gunter, Marc J
K1 diet
K1 nutrition
K1 ovarian cancer
K1 prospective cohort
K1 saturated fat
K1 serous
AB Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41). In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
YR 2015
FD 2015-11-25
LK http://hdl.handle.net/10668/9635
UL http://hdl.handle.net/10668/9635
LA en
DS RISalud
RD Apr 7, 2025