RT Journal Article
T1 Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
A1 Colomer, R
A1 Aranda-López, I
A1 Albanell, J
A1 García-Caballero, T
A1 Ciruelos, E
A1 López-García, M Á
A1 Cortés, J
A1 Rojo, F
A1 Martín, M
A1 Palacios-Calvo, J
K1 Breast neoplasm
K1 Diagnostic
K1 Gene expression profiling
K1 Prognostic
K1 Therapy predictive
AB This consensus statement revises and updates the recommendations for biomarkers use in the diagnosis and treatment of breast cancer, and is a joint initiative of the Spanish Society of Medical Oncology and the Spanish Society of Pathology. This expert group recommends determining in all cases of breast cancer the histologic grade and the alpha-estrogen receptor (ER), progesterone receptor, Ki-67 and HER2 status, in order to assist prognosis and establish therapeutic options, including hormone therapy, chemotherapy and anti-HER2 therapy. One of the four available genetic prognostic platforms (MammaPrint®, Oncotype DX®, Prosigna® or EndoPredict®) may be used in node-negative ER-positive patients to establish a prognostic category and decide with the patient whether adjuvant treatment may be limited to hormonal therapy. Newer technologies including next-generation sequencing, liquid biopsy, tumour-infiltrating lymphocytes or PD-1 determination are at this point investigational.
YR 2017
FD 2017-12-22
LK http://hdl.handle.net/10668/11946
UL http://hdl.handle.net/10668/11946
LA en
DS RISalud
RD Apr 10, 2025