RT Journal Article
T1 Novel Treatments for Age-Related Macular Degeneration: A Review of Clinical Advances in Sustained Drug Delivery Systems.
A1 Jimenez-Gomez, Yolanda
A1 Alba-Molina, David
A1 Blanco-Blanco, Mario
A1 Perez-Fajardo, Lorena
A1 Reyes-Ortega, Felisa
A1 Ortega-Llamas, Laura
A1 Villalba-Gonzalez, Marta
A1 Fernandez-Choquet de Isla, Ignacio
A1 Pugliese, Francisco
A1 Stoikow, Indira
A1 Gonzalez-Andrades, Miguel
K1 Age-related macular degeneration
K1 Clinical trials
K1 Sustained drug delivery system
AB In recent years, the number of patients with ocular diseases is increasing as a consequence of population aging. Among them, one of the most common is the age-related macular degeneration (AMD), a condition that leads to vision loss if it is not treated. AMD is a multifactorial disorder with two advanced forms, dry and neovascular AMD. Currently, although there is no approved therapy that significantly impacts dry AMD progression, several pharmacologic therapies exist for neovascular AMD. Notwithstanding, evidence suggests a suboptimal result in a high number of patients receiving these therapeutic options. Consequently, finding effective strategies is not only a still unmet medical need in dry AMD but also in neovascular AMD. This underlines the need for new drug delivery technologies that can improve the pharmacological action and drug concentration at the target sites. In this regard, sustained drug delivery systems are presented as the most promising therapeutic options in AMD patients. This review summarized the pathogenesis and the current treatment options for AMD, focusing on the emerging ocular sustained drug delivery approaches undergoing clinical trials.
PB MDPI
SN 1999-4923
YR 2022
FD 2022-07-13
LK http://hdl.handle.net/10668/21555
UL http://hdl.handle.net/10668/21555
LA en
NO Jiménez-Gómez Y, Alba-Molina D, Blanco-Blanco M, Pérez-Fajardo L, Reyes-Ortega F, Ortega-Llamas L, et al.  Novel Treatments for Age-Related Macular Degeneration: A Review of Clinical Advances in Sustained Drug Delivery Systems. Pharmaceutics. 2022 Jul 15;14(7):1473
DS RISalud
RD Apr 7, 2025