RT Journal Article
T1 DNA Methylation in infants with low and high body fatness
A1 Henriksson, Pontus
A1 Lentini, Antonio
A1 Altmäe, Signe
A1 Brodin, David
A1 Müller, Patrick
A1 Forsum, Elisabet
A1 Nestor, Colm E.
A1 Löf, Marie
K1 DNA Methylation
K1 Birth weight
K1 Body composition
K1 Body mass index
K1 Obesity
K1 Epigenetic
K1 Metilación de ADN
K1 Peso al nacer
K1 Composición corporal
K1 Índice de masa corporal
K1 Obesidad
K1 Epigenómica
AB Background: Birth weight is determined by the interplay between infant genetics and the intrauterine environment and is associated with several health outcomes in later life. Many studies have reported an association between birth weight and DNA methylation in infants and suggest that altered epigenetics may underlie birthweight-associated health outcomes. However, birth weight is a relatively nonspecific measure of fetal growth and consists of fat mass and fat-free mass which may have different effects on health outcomes which motivates studies of infant body composition and DNA methylation. Here, we combined genome-wide DNA methylation profiling of buccal cells from 47 full-term one-week old infants with accurate measurements of infant fat mass and fat-free mass using air-displacement plethysmography.Results: No significant association was found between DNA methylation in infant buccal cells and infant body composition. Moreover, no association between infant DNA methylation and parental body composition or indicators of maternal glucose metabolism were found. Conclusions: Despite accurate measures of body composition, we did not identify any associations between infant body fatness and DNA methylation. These results are consistent with recent studies that generally have identified only weak associations between DNA methylation and birthweight. Although our results should be confirmed by additional larger studies, our findings may suggest that differences in DNA methylation between individuals with low and high body fatness may be established later in childhood.
PB BioMed Central, Springer Nature
YR 2020
FD 2020-11-09
LK http://hdl.handle.net/10668/4146
UL http://hdl.handle.net/10668/4146
LA en
NO Henriksson P, Lentini A, Altmäe S, Brodin D, Müller P, Forsum E, et al. DNA methylation in infants with low and high body fatness. BMC Genomics. 2020 Nov 9;21(1):769
DS RISalud
RD Apr 7, 2025