RT Journal Article
T1 A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects
A1 Rosado-Sanchez, I.
A1 Herrero-Fernandez, I.
A1 Alvarez-Rios, A. I.
A1 Genebat, M.
A1 Abad-Carrillo, M. A.
A1 Ruiz-Mateos, E.
A1 Pulido, F.
A1 Gonzalez-Garcia, J.
A1 Montero, M.
A1 Bernal-Morell, E.
A1 Vidal, F.
A1 Leal, M.
A1 Pacheco, Y. M.
K1 CD4/CD8 T-cell ratio
K1 delayed cART
K1 low CD4 recovery
K1 T-cell turnover
K1 thymic function
K1 CD4/CD8 ratio
K1 antiretroviral therapy
K1 human immunodeficiency virus
K1 immunodiscordant
K1 Immunodeficiency-virus type-1
K1 Cd4 recovery
K1 Tropism
K1 Turnover
K1 Events
K1 Switch
K1 Naive
K1 Cart
K1 Risk
AB We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.
PB Amer soc microbiology
SN 0066-4804
YR 2017
FD 2017-07-25
LK http://hdl.handle.net/10668/19000
UL http://hdl.handle.net/10668/19000
LA en
NO Rosado-Sánchez I, Herrero-Fernández I, Álvarez-Ríos AI, Genebat M, Abad-Carrillo MA, Ruiz-Mateos E, et al . A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00605-17.
DS RISalud
RD Apr 12, 2025