%0 Journal Article
%A Rosado-Sanchez, I.
%A Herrero-Fernandez, I.
%A Alvarez-Rios, A. I.
%A Genebat, M.
%A Abad-Carrillo, M. A.
%A Ruiz-Mateos, E.
%A Pulido, F.
%A Gonzalez-Garcia, J.
%A Montero, M.
%A Bernal-Morell, E.
%A Vidal, F.
%A Leal, M.
%A Pacheco, Y. M.
%T A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects
%D 2017
%@ 0066-4804
%U http://hdl.handle.net/10668/19000
%X We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.
%K CD4/CD8 T-cell ratio
%K delayed cART
%K low CD4 recovery
%K T-cell turnover
%K thymic function
%K CD4/CD8 ratio
%K antiretroviral therapy
%K human immunodeficiency virus
%K immunodiscordant
%K Immunodeficiency-virus type-1
%K Cd4 recovery
%K Tropism
%K Turnover
%K Events
%K Switch
%K Naive
%K Cart
%K Risk
%~