RT Journal Article
T1 Positioning Europe for the EPITRANSCRIPTOMICS challenge.
A1 Jantsch, Michael F
A1 Quattrone, Alessandro
A1 O'Connell, Mary
A1 Helm, Mark
A1 Frye, Michaela
A1 Macias-Gonzales, Manuel
A1 Ohman, Marie
A1 Ameres, Stefan
A1 Willems, Luc
A1 Fuks, Francois
A1 Oulas, Anastasis
A1 Vanacova, Stepanka
A1 Nielsen, Henrik
A1 Bousquet-Antonelli, Cecile
A1 Motorin, Yuri
A1 Roignant, Jean-Yves
A1 Balatsos, Nikolaos
A1 Dinnyes, Andras
A1 Baranov, Pavel
A1 Kelly, Vincent
A1 Lamm, Ayelet
A1 Rechavi, Gideon
A1 Pelizzola, Mattia
A1 Liepins, Janis
A1 Holodnuka Kholodnyuk, Irina
A1 Zammit, Vanessa
A1 Ayers, Duncan
A1 Drablos, Finn
A1 Dahl, John Arne
A1 Bujnicki, Janusz
A1 Jeronimo, Carmen
A1 Almeida, Raquel
A1 Neagu, Monica
A1 Costache, Marieta
A1 Bankovic, Jasna
A1 Banovic, Bojana
A1 Kyselovic, Jan
A1 Valor, Luis Miguel
A1 Selbert, Stefan
A1 Pir, Pinar
A1 Demircan, Turan
A1 Cowling, Victoria
A1 Schäfer, Matthias
A1 Rossmanith, Walter
A1 Lafontaine, Denis
A1 David, Alexandre
A1 Carre, Clement
A1 Lyko, Frank
A1 Schaffrath, Raffael
A1 Schwartz, Schraga
A1 Verdel, Andre
A1 Klungland, Arne
A1 Purta, Elzbieta
A1 Timotijevic, Gordana
A1 Cardona, Fernando
A1 Davalos, Alberto
A1 Ballana, Ester
A1 O Carroll, Donal
A1 Ule, Jernej
A1 Fray, Rupert
K1 European funding
K1 database of Modification
K1 detection of RNA modification
K1 epitranscriptomics
K1 model systems
AB The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
YR 2018
FD 2018-05-09
LK http://hdl.handle.net/10668/12369
UL http://hdl.handle.net/10668/12369
LA en
DS RISalud
RD Apr 5, 2025