TY  - JOUR
AU  - Hernandez-Camarero, Pablo
AU  - Lopez-Ruiz, Elena
AU  - Griñan-Lison, Carmen
AU  - Garcia, Maria Angel
AU  - Chocarro-Wrona, Carlos
AU  - Marchal, Juan Antonio
AU  - Kenyon, Julian
AU  - Peran, Macarena
PY  - 2019
DO  - 10.1038/s41598-019-47837-7
UR  - http://hdl.handle.net/10668/14370
T2  - Scientific reports
AB  - Cancer stem cells (CSCs) subpopulation within the tumour is responsible for metastasis and cancer relapse. Here we investigate in vitro and in vivo the effects of a pancreatic (pro)enzyme mixture composed of Chymotrypsinogen and Trypsinogen (PRP) on...
LA  - en
PB  - Nature Publishing Group
KW  - Drug development
KW  - Cancer stem cells
KW  - Chymotrypsinogen
KW  - Genes, Tumor Suppressor
KW  - Mice, Nude
KW  - Animals
KW  - Cell Line, Tumor
KW  - Epithelial-Mesenchymal Transition
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - MAP Kinase Signaling System
KW  - Mice
KW  - Neoplastic Stem Cells
KW  - Pancreatic Neoplasms
KW  - Trypsinogen
KW  - Xenograft Model Antitumor Assays
TI  - Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting.
TY  - research article
VL  - 9
ER  -