RT Journal Article
T1 Lung transplantation for cystic fibrosis: differential characteristics and outcomes between children and adults.
A1 Moreno, Paula
A1 Alvarez, Antonio
A1 Carrasco, Guadalupe
A1 Redel, Javier
A1 Guaman, Hugo Dario
A1 Baamonde, Carlos
A1 Algar, Francisco Javier
A1 Cerezo, Francisco
A1 Salvatierra, Angel
K1 Adults
K1 Cystic fibrosis
K1 Lung transplantation
K1 Outcomes
K1 Paediatrics
AB The survival benefit of lung transplantation (LTx) for cystic fibrosis (CF) patients is well demonstrated. We aim to compare children and adult CF recipients to assess whether there are differences in survival and clinical outcomes, and to identify risk factors for mortality. A retrospective analysis of 442 consecutive LTx performed at our institution in a 20-year period was conducted. CF patients were distributed into two groups: children (age  The study group included 120 consecutive CF patients: 50 children (13 ± 3 years) and 70 adults (25 ± 6 years) undergoing 111 bilateral, 4 lobar, 4 combined and 1 unilateral LTx. Comparative analysis (children versus adults): survival (overall; 5, 10 and 15 years) 57, 45, 35% vs 67, 55, 43% (P = 0.32); survival (1-year survivors; 5, 10 and 15 years): 75, 64, 46% vs 90, 75, 59% (P = 0.09); 30-day mortality: 14 vs 16% (P = 0.27); urgent LTx: 32 vs 17% (P = 0.04); use of cardiopulmonary bypass (CPB): 56 vs 28% (P = 0.002); intensive care unit stay: 20 ± 19 vs 10 ± 9 days (P = 0.006); AR episodes (n): 1.4 ± 0.7 vs 1.2 ± 0.8 (P = 0.004). Incidence of PGD and freedom from CLAD did not differ between groups. Predictors of mortality were: use of CPB (HR 3.12; 95% CI 1.33-7.35; P  Paediatric CF patients usually present with poorer pre-transplant status, require CPB more frequently and have a higher incidence of post-LTx diabetes and infections. This might explain the trend towards a better long-term survival observed in adult CF patients.
PB Oxford University Press
YR 2015
FD 2015-09-10
LK http://hdl.handle.net/10668/9611
UL http://hdl.handle.net/10668/9611
LA en
NO Moreno P, Alvarez A, Carrasco G, Redel J, Guaman HD, Baamonde C, et al. Lung transplantation for cystic fibrosis: differential characteristics and outcomes between children and adults. Eur J Cardiothorac Surg. 2016 May;49(5):1334-43
DS RISalud
RD Apr 17, 2025