TY - JOUR AU - Cubillos-Zapata, Carolina AU - Martínez-García, Miguel Ángel AU - Díaz-García, Elena AU - Jaureguizar, Ana AU - Campos-Rodríguez, Francisco AU - Sánchez-de-la-Torre, Manuel AU - Nagore, Eduardo AU - Martorell-Calatayud, Antonio AU - Hernández Blasco, Luis AU - Pastor, Esther AU - Abad-Capa, Jorge AU - Montserrat, Josep María AU - Cabriada-Nuño, Valentín AU - Cano-Pumarega, Irene AU - Corral-Peñafiel, Jaime AU - Arias, Eva AU - Mediano, Olga AU - Somoza-González, María AU - Dalmau-Arias, Joan AU - Almendros, Isaac AU - Farré, Ramón AU - López-Collazo, Eduardo AU - Gozal, David AU - García-Río, Francisco PY - 2020 DO - 10.1038/s41598-020-72481-x UR - http://hdl.handle.net/10668/4309 T2 - Scientific Reports AB - Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in... LA - en PB - Springer Nature KW - TGF‑ß1 KW - Transforming growth factor beta1 KW - Skin neoplasms KW - Tumor KW - Obesity KW - Apnea KW - Leptin KW - Sleep KW - Factor de crecimiento transformador beta1 KW - Neoplasias cutáneas KW - Obesidad KW - Leptina KW - Sueño KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptin KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Melanoma KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Skin Neoplasms KW - Medical Subject Headings::Diseases::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, Obstructive KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Transforming Growth Factor beta::Transforming Growth Factor beta1 KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytogenetic Analysis::Mitotic Index KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Sleep TI - Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma TY - research article ER -