RT Journal Article
T1 Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma
A1 Cubillos-Zapata, Carolina
A1 Martínez-García, Miguel Ángel
A1 Díaz-García, Elena
A1 Jaureguizar, Ana
A1 Campos-Rodríguez, Francisco
A1 Sánchez-de-la-Torre, Manuel
A1 Nagore, Eduardo
A1 Martorell-Calatayud, Antonio
A1 Hernández Blasco, Luis
A1 Pastor, Esther
A1 Abad-Capa, Jorge
A1 Montserrat, Josep María
A1 Cabriada-Nuño, Valentín
A1 Cano-Pumarega, Irene
A1 Corral-Peñafiel, Jaime
A1 Arias, Eva
A1 Mediano, Olga
A1 Somoza-González, María
A1 Dalmau-Arias, Joan
A1 Almendros, Isaac
A1 Farré, Ramón
A1 López-Collazo, Eduardo
A1 Gozal, David
A1 García-Río, Francisco
K1 TGF‑ß1
K1 Transforming growth factor beta1
K1 Skin neoplasms
K1 Tumor
K1 Obesity
K1 Apnea
K1 Leptin
K1 Sleep
K1 Factor de crecimiento transformador beta1
K1 Neoplasias cutáneas
K1 Obesidad
K1 Leptina
K1 Sueño
AB Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in patients with cutaneous melanoma (CM), assess their relationship with melanoma aggressiveness and analyze the factors related to TGF-β1 levels in obese and non-obese OSA patients. In a multicenter observational study, 290 patients with CM were underwent sleep studies. TGF-β1 was increased in moderate-severe OSA patients vs. non-OSA or mild OSA patients with CM. In OSA patients, TGF-β1 levels correlated with mitotic index, Breslow index and melanoma growth rate, and were increased in presence of ulceration or higher Clark levels. In CM patients, OSA was associated with higher TGF-β1 levels and greater melanoma aggressiveness only in non-obese subjects. An in vitro model showed that IH-induced increases of TGF-β1 expression in melanoma cells is attenuated in the presence of high leptin levels. In conclusion, TGF-β1 levels are associated with melanoma aggressiveness in CM patients and increased in moderate-severe OSA. Moreover, in non-obese patients with OSA, TGF-β1 levels correlate with OSA severity and leptin levels, whereas only associate with leptin levels in obese OSA patients.
PB Springer Nature
YR 2020
FD 2020-09-23
LK http://hdl.handle.net/10668/4309
UL http://hdl.handle.net/10668/4309
LA en
NO Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, Jaureguizar A, Campos-Rodríguez F, Sánchez-de-la-Torre M, et al. Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma. Sci Rep. 2020 Sep 23;10(1):15528
DS RISalud
RD Apr 11, 2025