TY - JOUR AU - Fransson, Jennifer AU - Gómez-Conde, Ana Isabel AU - Romero-Imbroda, Jesús AU - Fernández, Oscar AU - Leyva, Laura AU - de Fonseca, Fernando Rodríguez AU - Chun, Jerold AU - Louapre, Celine AU - Van-Evercooren, Anne Baron AU - Zujovic, Violetta AU - Estivill-Torrús, Guillermo AU - García-Díaz, Beatriz PY - 2020 DO - 10.1007/s12035-020-02130-x UR - http://hdl.handle.net/10668/16313 T2 - Molecular neurobiology AB - Multiple sclerosis (MS) is a neuroinflammatory disease whose pathogenesis remains unclear. Lysophosphatidic acid (LPA) is an endogenous phospholipid involved in multiple immune cell functions and dysregulated in MS. Its receptor LPA1 is expressed in... LA - en KW - Experimental autoimmune encephalomyelitis KW - Inflammation KW - LPA1 receptor KW - Lysophosphatidic acid KW - Macrophages KW - Multiple sclerosis KW - Adolescent KW - Adult KW - Aged KW - Animals KW - Cell Polarity KW - Central Nervous System KW - Encephalomyelitis, Autoimmune, Experimental KW - Female KW - Humans KW - Inflammation KW - Lysophospholipids KW - Macrophage Activation KW - Macrophages KW - Mice, Inbred C57BL KW - Middle Aged KW - Monocytes KW - Multiple Sclerosis KW - PPAR gamma KW - Phenotype KW - Receptors, Lysophosphatidic Acid KW - Recurrence KW - Young Adult TI - Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis. TY - research article VL - 58 ER -