TY - JOUR AU - Ibanez-Costa, Alejandro AU - Perez-Sanchez, Carlos AU - Patino-Trives, Alejandra Maria AU - Luque-Tevar, Maria AU - Font, Pilar AU - Arias de la Rosa, Ivan AU - Roman-Rodriguez, Cristobal AU - Abalos-Aguilera, Ma Carmen AU - Conde, Carmen AU - Gonzalez, Antonio AU - Pedraza-Arevalo, Sergio AU - del Rio-Moreno, Mercedes AU - Blazquez-Encinas, Ricardo AU - Segui, Pedro AU - Calvo, Jerusalem AU - Ortega Castro, Rafaela AU - Escudero-Contreras, Alejandro AU - Barbarroja, Nuria AU - Aguirre, Ma Angeles AU - Castano-Fuentes, Justo P. AU - Luque, Raul M. AU - Collantes-Estevez, Eduardo AU - Lopez-Pedrera, Chary PY - 2021 DO - 10.1136/annrheumdis-2021-220308 SN - 0003-4967 UR - https://hdl.handle.net/10668/25884 T2 - Annals of the rheumatic diseases AB - Objectives To characterise splicing machinery (SM) alterations in leucocytes of patients with rheumatoid arthritis (RA), and to assess its influence on their clinical profile and therapeutic response. Methods Leucocyte subtypes from 129 patients with... LA - en PB - Bmj publishing group KW - rheumatoid arthritis KW - anti-citrullinated protein antibodies KW - biological therapy KW - tumor necrosis factor inhibitors KW - Functional-significance KW - Developmental disorder KW - American-college KW - Expression KW - Variants KW - Phosphorylation KW - Autoimmunity KW - Fibronectin KW - Transcript KW - Antibodies TI - Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy TY - research article VL - 81 ER -