RT Journal Article
T1 In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study.
A1 Grothe, Michel J
A1 Labrador-Espinosa, Miguel A
A1 Jesús, Silvia
A1 Macías-García, Daniel
A1 Adarmes-Gómez, Astrid
A1 Carrillo, Fátima
A1 Camacho, Elena Iglesias
A1 Franco-Rosado, Pablo
A1 Lora, Florinda Roldán
A1 Martín-Rodríguez, Juan Francisco
A1 Barberá, Miquel Aguilar
A1 Pastor, Pau
A1 Arroyo, Sonia Escalante
A1 Vila, Berta Solano
A1 Foraster, Anna Cots
A1 Martínez, Javier Ruiz
A1 Padilla, Francisco Carrillo
A1 Morlans, Mercedes Pueyo
A1 Aramburu, Isabel González
A1 Ceberio, Jon Infante
A1 Vara, Jorge Hernández
A1 de Fábregues-Boixar, Oriol
A1 de Deus Fonticoba, Teresa
A1 Pascual-Sedano, Berta
A1 COPPADIS Study Group, 
A1 Kulisevsky, Jaime
A1 Martínez-Martín, Pablo
A1 Santos-García, Diego
A1 Mir, Pablo
K1 DTI
K1 Diffusion
K1 MRI
K1 Nucleus basalis Meynert
K1 Parkinson's disease
K1 Substantia innominata
AB We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p  Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.
YR 2021
FD 2021-05-31
LK http://hdl.handle.net/10668/18017
UL http://hdl.handle.net/10668/18017
LA en
DS RISalud
RD Apr 21, 2025