RT Journal Article
T1 In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study.
A1 Grothe, Michel J
A1 Labrador-Espinosa, Miguel A
A1 Jesus, Silvia
A1 Macias-Garcia, Daniel
A1 Adarmes-Gomez, Astrid
A1 Carrillo, Fátima
A1 Iglesias-Camacho, Elena
A1 Franco-Rosado, Pablo
A1 Roldan-Lora, Florinda
A1 Martin-Rodriguez, Juan Francisco
A1 Aguilar-Barbera, Miquel
A1 Pastor, Pau
A1 Escalante-Arroyo, Sonia
A1 Solano-Vila, Berta
A1 Cots-Foraster, Anna
A1 Ruiz-Martinez, Javier
A1 Carrillo-Padilla, Francisco
A1 Pueyo-Morlans, Mercedes
A1 Gonzalez-Aramburu, Isabel
A1 Infante-Ceberio, Jon
A1 Hernandez-Vara, Jorge
A1 de-Fabregues-Boixar, Oriol
A1 de-Deus-Fonticoba, Teresa
A1 Pascual-Sedano, Berta
A1 Kulisevsky, Jaime
A1 Martinez-Martin, Pablo
A1 Santos-Garcia, Diego
A1 Mir, Pablo
K1 DTI
K1 Diffusion
K1 MRI
K1 Nucleus basalis Meynert
K1 Parkinson's disease
K1 Substantia innominata
AB We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models. Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRStotal: r = 0.37, p  Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.
PB Elsevier Ltd
SN 1353-8020
YR 2021
FD 2021-05-31
LK http://hdl.handle.net/10668/18017
UL http://hdl.handle.net/10668/18017
LA en
NO Grothe MJ, Labrador-Espinosa MA, Jesús S, Macías-García D, Adarmes-Gómez A, Carrillo F, et al. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study. Parkinsonism Relat Disord. 2021 Jul;88:68-75.
DS RISalud
RD Jul 6, 2025