%0 Journal Article
%A Carbonell, Raquel
%A Urgelés, Silvia
%A Salgado, Melina
%A Rodríguez, Alejandro
%A Reyes, Luis Felipe
%A Fuentes, Yuli V
%A Serrano, Cristian C
%A Caceres, Eder L
%A Bodí, María
%A Martín-Loeches, Ignacio
%A Solé-Violán, Jordi
%A Díaz, Emili
%A Gómez, Josep
%A Trefler, Sandra
%A Vallverdú, Montserrat
%A Murcia, Josefa
%A Albaya, Antonio
%A Loza, Ana
%A Socias, Lorenzo
%A Ballesteros, Juan Carlos
%A Papiol, Elisabeth
%A Viña, Lucía
%A Sancho, Susana
%A Nieto, Mercedes
%A Del, M
%A Lorente, Carmen
%A Badallo, Oihane
%A Fraile, Virginia
%A Arméstar, Fernando
%A Estella, Angel
%A Abanses, Paula
%A Sancho, Isabel
%A Guasch, Neus
%A Moreno, Gerard
%A COVID-19 SEMICYUC Working Group and the LIVEN-Covid-19 Investigators
%T Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patients.
%D 2022
%U http://hdl.handle.net/10668/22321
%X Procalcitonin (PCT) and C-Reactive Protein (CRP) are useful biomarkers to differentiate bacterial from viral or fungal infections, although the association between them and co-infection or mortality in COVID-19 remains unclear. The study represents a retrospective cohort study of patients admitted for COVID-19 pneumonia to 84 ICUs from ten countries between (March 2020-January 2021). Primary outcome was to determine whether PCT or CRP at admission could predict community-acquired bacterial respiratory co-infection (BC) and its added clinical value by determining the best discriminating cut-off values. Secondary outcome was to investigate its association with mortality. To evaluate the main outcome, a binary logistic regression was performed. The area under the curve evaluated diagnostic performance for BC prediction. 4635 patients were included, 7.6% fulfilled BC diagnosis. PCT (0.25[IQR 0.1-0.7] versus 0.20[IQR 0.1-0.5]ng/mL, p These biomarkers at ICU admission led to a poor ability to predict BC among patients with COVID-19 pneumonia. Baseline values of PCT
%K Bacterial co-infection
%K C-reactive protein
%K Covid-19 pneumonia
%K Mortality
%K Procalcitonin
%~