TY  - JOUR
AU  - Martínez-Rubio, Álvaro
AU  - Chulián, Salvador
AU  - Blázquez Goñi, Cristina
AU  - Ramírez Orellana, Manuel
AU  - Pérez Martínez, Antonio
AU  - Navarro-Zapata, Alfonso
AU  - Ferreras, Cristina
AU  - Pérez-García, Victor M.
AU  - Rosa, María
PY  - 2021
DO  - 10.3390/ijms22126371
UR  - http://hdl.handle.net/10668/4478
T2  - International Journal of Molecular Sciences
AB  - Chimeric Antigen Receptor (CAR) T-cell therapy has demonstrated high rates of response in recurrent B-cell Acute Lymphoblastic Leukemia in children and young adults. Despite this success, a fraction of patients' experience relapse after treatment....
LA  - en
PB  - MDPI
KW  - CAR T
KW  - Mathematical model
KW  - Acute lymphoblastic leukemia
KW  - B cell
KW  - Bone marrow
KW  - Receptores quiméricos de antígenos
KW  - Modelos teóricos
KW  - Leucemia-linfoma linfoblástico de células precursoras
KW  - Subgrupos de linfocitos B
KW  - Médula ósea
KW  - Niño
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::B-Lymphocytes
KW  - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Child
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunologic Memory
KW  - Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma::Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization::Immunization, Passive::Adoptive Transfer::Immunotherapy, Adoptive
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical
KW  - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::B-Lymphocyte Subsets
TI  - A Mathematical Description of the Bone Marrow Dynamics during CAR T-Cell Therapy in B-Cell Childhood Acute Lymphoblastic Leukemia
TY  - research article
ER  -