RT Journal Article
T1 Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study.
A1 Luperdi, Sussy C
A1 Correa-Ghisays, Patricia
A1 Vila-Francés, Joan
A1 Selva-Vera, Gabriel
A1 Salazar-Fraile, José
A1 Cardoner, Narcís
A1 Ruiz-Veguilla, Miguel
A1 Livianos, Lorenzo
A1 Tabarés-Seisdedos, Rafael
A1 Balanzá-Martínez, Vicent
K1 Bipolar disorder
K1 Cognition
K1 Endophenotype
K1 Family study
K1 Longitudinal study
K1 Processing speed
AB Substantial evidence supports the existence of neurocognitive endophenotypes in bipolar disorder (BD), but very few longitudinal studies have included unaffected relatives. In a 5-year, follow-up, family study, we have recently suggested that deficits in manual motor speed and visual memory could be endophenotype candidates for BD. We aimed to explore whether this also applies to processing speed. A sample of 348 individuals, including 163 BD patients, 65 unaffected first-degree relatives (BD-Rel) and 120 genetically unrelated healthy controls (HC), was assessed with the Digit Symbol Substitution Test (DSST) on two occasions over a 2-year period (T1, T2). DSST values were controlled for age, years of education, occupational status, and subsyndromic mood symptoms. Differences between groups were evaluated with ANCOVAs. At T1 BD performed significantly worse than HC (p  0.05). The results of this longitudinal, family study suggest that impaired processing speed may represent a suitable cognitive endophenotype for BD. Further research on the field is required to confirm these preliminary findings.
YR 2021
FD 2021-07-06
LK http://hdl.handle.net/10668/18195
UL http://hdl.handle.net/10668/18195
LA en
DS RISalud
RD Apr 7, 2025