RT Journal Article
T1 Design and validation of a predictive model for 1-year hospital admission in HIV patients on antiretroviral treatment
A1 Montes-Escalante, Ines
A1 Monje-Agudo, Patricia
A1 Calvo-Cidoncha, Elena
A1 Almeida-Gonzalez, Carmen V.
A1 Morillo-Verdugo, Ramon
K1 Drug-interactions
K1 Risk
K1 Comorbidity
K1 Readmission
K1 Polypharmacy
AB Objectives To develop and validate a model for predicting the risk of hospital admission within 1 year in the HIV population under antiretroviral treatment.Methods We conducted a retrospective observational study. Patients receiving antiretroviral treatment for at least 1 year who were followed by the pharmacy service in a Spanish-speaking hospital between January 2008 and December 2012 were included. Demographics, and clinical and pharmacotherapy variables, were included in the model design. To find prognostic factors for hospital admission a multivariate logistic regression model was created after performing a univariate analysis. Model validity was determined by the shrinkage method and the model discrimination by Harrell's C-index.Results 442 patients were included in the study. The variables 'CD4 count 50 copies/mL)', 'number of previous admissions', and 'number of drugs different from antiretroviral treatment' were the independent predictors of risk of hospital admission. Probabilities predicted by the model showed an R-2=0.98 for the development sample and an R-2=0.86 for the validation sample. The Harrell's C index for the development and validation data were 0.82 (95% CI 0.77 to 0.87) and 0.80 (95% CI 0.73 to 0.88), respectively.Conclusions The model developed in this study may be useful in daily practice for identifying HIV patients at high risk of 1-year hospital admission.
PB Bmj publishing group
SN 2047-9956
YR 2016
FD 2016-07-01
LK http://hdl.handle.net/10668/19034
UL http://hdl.handle.net/10668/19034
LA en
DS RISalud
RD Jul 31, 2025