RT Journal Article
T1 Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis.
A1 Di Marco, Andrea
A1 Anguera, Ignasi
A1 Schmitt, Matthias
A1 Klem, Igor
A1 Neilan, Tomas G
A1 White, James A
A1 Sramko, Marek
A1 Masci, Pier Giorgio
A1 Barison, Andrea
A1 Mckenna, Peter
A1 Mordi, Ify
A1 Haugaa, Kristina H
A1 Leyva, Francisco
A1 Rodriguez Capitán, Jorge
A1 Satoh, Hiroshi
A1 Nabeta, Takeru
A1 Dallaglio, Paolo Domenico
A1 Campbell, Niall G
A1 Sabaté, Xavier
A1 Cequier, Ángel
K1 cardiac magnetic resonance
K1 dilated cardiomyopathy
K1 late gadolinium enhancement
K1 sudden death
K1 ventricular arrhythmias
AB The aim of this study was to evaluate the association between late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging and ventricular arrhythmias or sudden cardiac death (SCD) in patients with dilated cardiomyopathy (DCM). Risk stratification for SCD in DCM needs to be improved. A systematic review and meta-analysis were conducted. A systematic search of PubMed and Ovid was performed, and observational studies that analyzed the arrhythmic endpoint (sustained ventricular arrhythmia, appropriate implantable cardioverter-defibrillator [ICD] therapy, or SCD) in patients with DCM, stratified by the presence or absence of LGE, were included. Twenty-nine studies were included, accounting for 2,948 patients. The studies covered a wide spectrum of DCM, with a mean left ventricular ejection fraction between 20% and 43%. LGE was significantly associated with the arrhythmic endpoint both in the overall population (odds ratio: 4.3; p 35% (odds ratio: 5.2; p  Across a wide spectrum of patients with DCM, LGE is strongly and independently associated with ventricular arrhythmia or SCD. LGE could be a powerful tool to improve risk stratification for SCD in patients with DCM. These results raise 2 major questions to be addressed in future studies: whether patients with LGE could benefit from primary prevention ICDs irrespective of their left ventricular ejection fractions, while patients without LGE might not need preventive ICDs despite having severe left ventricular dysfunction.
YR 2016
FD 2016-12-21
LK http://hdl.handle.net/10668/10712
UL http://hdl.handle.net/10668/10712
LA en
DS RISalud
RD Apr 18, 2025