RT Journal Article
T1 Low intensity vs. self-guided internet-delivered psychotherapy for major depression: a multicenter, controlled, randomized study.
A1 López-del-Hoyo, Yolanda
A1 Olivan, Barbara
A1 Luciano, Juan V
A1 Mayoral, Fermín
A1 Roca, Miquel
A1 Gili, Margalida
A1 Andres, Eva
A1 Serrano-Blanco, Antoni
A1 Collazo, Francisco
A1 Araya, Ricardo
A1 Baños, Rosa
A1 Botella, Cristina
A1 Magallón, Rosa
A1 García-Campayo, Javier
K1 Depression
K1 Computer-delivered psychotherapy
K1 Randomized controlled trial
K1 Trastorno depresivo mayor
K1 Diseño de la investigación
K1 Tratamiento asistido por ordenador
K1 Resultado del tratamiento
K1 Protocolos clínicos
K1 Terapia cognitiva
K1 Análisis Costo-Beneficio
AB BACKGROUNDMajor depression will become the second most important cause of disability in 2020. Computerized cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment. No studies on cost-effectiveness of low intensity vs self-guided psychotherapy has been carried out. The aim of this study is to assess the efficacy of low intensity vs self-guided psychotherapy for major depression in the Spanish health system.METHODSThe study is made up of 3 phases: 1.- Development of a computerized cognitive-behaviour therapy for depression tailored to Spanish health system. 2.- Multicenter controlled, randomized study: A sample (N=450 patients) with mild/moderate depression recruited in primary care. They should have internet availability at home, not receive any previous psychological treatment, and not suffer from any other severe somatic or psychological disorder. They will be allocated to one of 3 treatments: a) Low intensity Internet-delivered psychotherapy + improved treatment as usual (ITAU) by GP, b) Self-guided Internet-delivered psychotherapy + ITAU or c) ITAU. Patients will be diagnosed with MINI psychiatric interview. Main outcome variable will be Beck Depression Inventory. It will be also administered EuroQol 5D (quality of life) and Client Service Receipt Inventory (consume of health and social services). Patients will be assessed at baseline, 3 and 12 months. An intention to treat and a per protocol analysis will be performed.DISCUSSIONThe comparisons between low intensity and self-guided are infrequent, and also a comparative economic evaluation between them and compared with usual treatment in primary. The strength of the study is that it is a multicenter, randomized, controlled trial of low intensity and self-guided Internet-delivered psychotherapy for depression in primary care, being the treatment completely integrated in primary care setting.TRIAL REGISTRATIONClinical Trials NCT01611818.
PB BioMed Central
YR 2013
FD 2013-01-11
LK http://hdl.handle.net/10668/1394
UL http://hdl.handle.net/10668/1394
LA en
NO López-del-Hoyo Y, Olivan B, Luciano JV, Mayoral F, Roca M, Gili M, et al. Low intensity vs. self-guided internet-delivered psychotherapy for major depression: a multicenter, controlled, randomized study. BMC Psychiatry. 2013; 13:21
NO Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Trial registration: Clinical Trials NCT01611818
DS RISalud
RD Apr 6, 2025