RT Journal Article
T1 Factors associated with atherosclerosis in radiographic and non-radiographic axial spondyloarthritis. A multicenter study on 838 patients.
A1 Rueda-Gotor, Javier
A1 Ferraz-Amaro, Iván
A1 Genre, Fernanda
A1 González-Mazón, Iñigo
A1 Corrales, Alfonso
A1 Calvo-Rio, Vanesa
A1 Portilla, Virginia
A1 Llorca, Javier
A1 Expósito, Rosa
A1 Hernández-Hernández, Vanesa
A1 Quevedo-Abeledo, Juan Carlos
A1 Rodríguez-Lozano, Carlos
A1 Lopez-Medina, Clementina
A1 Ladehesa-Pineda, María Lourdes
A1 Castañeda, Santos
A1 Vicente, Esther F
A1 Fernández-Carballido, Cristina
A1 Martínez-Vidal, M Paz
A1 Castro-Corredor, David
A1 Anino-Fernández, Joaquín
A1 Peiteado, Diana
A1 Plasencia-Rodríguez, Chamaida
A1 García-Vivar, María Luz
A1 Galíndez-Agirregoikoa, Eva
A1 Montes-Perez, Esther
A1 Fernández-Díaz, Carlos
A1 Blanco, Ricardo
A1 González-Gay, Miguel Ángel
K1 Ankylosing spondylitis
K1 Atherosclerosis
K1 Cardiovascular
K1 Carotid ultrasound
K1 Non-radiographic spondyloarthritis
AB To identify disease-related factors associated with subclinical atherosclerosis and cardiovascular (CV) events in a large series of patients with axial spondyloarthritis (axSpA) and to identify possible differences in the effect of the potential pro-atherogenic factors between ankylosing spondylitis (AS) non-radiographic axSpA (nr-axSpA). This is a cross-sectional observational study of the AtheSpAin cohort, a Spanish multicenter cohort to study atherosclerosis in axSpA. Subclinical atherosclerosis determined by carotid ultrasound included assessment of carotid intima-media thickness (cIMT) and plaque detection. 639 AS and 167 nr-axSpA patients were recruited. CV risk factors (CRF) and several disease-related factors showed a statistically significant association with subclinical atherosclerosis in the crude analysis. After adjustment for age, sex, and smoking (model 1), associations remained statistically significant for spinal mobility, inflammatory bowel disease, use of prednisone, and Disease-modifying antirheumatic drugs (DMARD) when assessing carotid plaques and for acute phase reactants (APR) at diagnosis, use of prednisone, DMARD, and TNF-inhibitors when measuring cIMT. In model 2, which also included classic CRF as confounding factors to identify axSpA features with a potential independent pro-atherogenic effect, the functional status was the only variable significantly associated with plaques and the use of prednisone and APR at diagnosis with cIMT. No association differences were found between both subtypes of patients. Besides, APR at diagnosis were also associated with subsequent development of CV events that had occurred in 33 patients. Apart from CRF, atherosclerotic disease in AxSpA is associated with disease-related factors such as inflammatory response and disease severity, with no differences between AS and nr-axSpA.
YR 2022
FD 2022-05-28
LK http://hdl.handle.net/10668/22514
UL http://hdl.handle.net/10668/22514
LA en
DS RISalud
RD Apr 5, 2025