RT Journal Article
T1 Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study.
A1 Molina-Montes, Esther
A1 Rodríguez-Barranco, Miguel
A1 Alcalá-Santiago, Ángela
A1 Gálvez-Navas, José María
A1 Huerta, José María
A1 Amiano, Pilar
A1 Lasheras, Cristina
A1 Moreno-Iribas, Conchi
A1 Jimenez-Zabala, Ana
A1 Chirlaque, María-Dolores
A1 Gasque, Alba
A1 Luján-Barroso, Leila
A1 Agudo, Antonio
A1 Jakszyn, Paula
A1 Quirós, José Ramón
A1 Sánchez, María José
K1 Anthropometry
K1 Chronobiology
K1 Circadian clock
K1 Diet habits
K1 Genetic association analyses
K1 Nutrition
AB Background & aims: Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the "European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet" study.Methods: The study population comprised 3,183 subjects with information on diet and twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). The associations between the variants with chrononutrition variables (macronutrients and serving sizes of each meal) were evaluated using linear regression, considering an additive genetic model, and adjusting for sex, age and center, among others. The β coefficients, 95 % confidence intervals (CI), and p-values corrected for multiple comparisons were estimated. A genetic risk score (GRS) that was associated to the evening/late chronotype as well as overweight/obesity in a previous study, the chronotype-GRS, was tested for its association with chrononutrition variables.Results: The nutritional profile of the diet differed according to the individual's chronotype, with evening/late chronotypes exhibiting an unbalanced intake during breakfast and dinner compared to the intermediate and early chronotypes (e.g., percentage of fats consumed at breakfast relative to the total fat intake: 13 % and 9 %, respectively). However, significant differences were not encountered by the chronotype-GRS. In multivariate analyses, individual associations between the genetic variants and the nutrients revealed some nominal associations (e.g., rs1801260 and rs2070062 with carbohydrates at breakfast: β = -0.06 to 0.08). Higher scorings of the chronotype-GRS were inversely associated with the intake of proteins and carbohydrates (β = -0.46 and -0.41; nominal p-value<0.006; corrected = 0.25) during breakfast. Also, there was an inverse association between the chronotype-GRS and the breakfast's portion size (β = -0.3; nominal p-value = 0.03; corrected = 0.1).Conclusions: Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content.
PB Elsevier
YR 2025
FD 2025-06
LK https://hdl.handle.net/10668/28517
UL https://hdl.handle.net/10668/28517
LA en
NO Molina-Montes E, Rodríguez-Barranco M, Alcalá-Santiago Á, Gálvez-Navas JM, Huerta JM, Amiano P, et al. Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study. Clin Nutr. 2025 Jun;49:165-177.
DS RISalud
RD Sep 13, 2025