%0 Journal Article
%A Ponde, Noam
%A Bradbury, Ian
%A Lambertini, Matteo
%A Ewer, Michael
%A Campbell, Christine
%A Ameels, Helene
%A Zardavas, Dimitrios
%A Di Cosimo, Serena
%A Baselga, José
%A Huober, Jens
%A Izquierdo, Miguel
%A Fumagalli, Debora
%A Bozovic-Spasojevic, Ivana
%A Maetens, Marion
%A Harbeck, Nadia
%A Pusztai, Lajos
%A Berghorn, Michael
%A Im, Young-Hyuck
%A Borrego, Manuel Ruiz
%A Chen, Dar-Ren
%A Rodeheffer, Richard
%A Piccart, Martine
%A Suter, Thomas
%A de Azambuja, Evandro
%T Cardiac biomarkers for early detection and prediction of trastuzumab and/or lapatinib-induced cardiotoxicity in patients with HER2-positive early-stage breast cancer: a NeoALTTO sub-study (BIG 1-06).
%D 2017
%U http://hdl.handle.net/10668/11951
%X Biomarkers of cardiac damages, such as troponin T (TnT) and the amino-terminal fragment of brain natriuretic peptide (NT-proBNP), may be useful as early predictors of cardiac dysfunction. The role of these biomarkers in patients receiving lapatinib and/or trastuzumab before anthracyclines is unknown. This study explores TnT and NT-proBNP as predictors of early cardiac toxicity in neoadjuvant breast cancer patients. This sub-study of the NEOALTTO trial tested if changes in the levels of TnT and NT-proBNP occurred after 2 weeks of anti-HER2 therapy (lapatinib, trastuzumab or their combination) alone and/or after 18 weeks of anti-HER2 therapy plus weekly paclitaxel. 173 and 172 were tested at all three timepoints for NT-proBNP and TnT, respectively. The incidence of biomarker elevation was overall low at all timepoints for all the three treatment arms. A total of 13 CEs in 11 patients occurred. Biomarker elevations in patients with CEs were very rare; only one patient with subsequent CE had a NT-proBNP elevation at baseline and at week 2. These results suggest that TnT and proBNP may not be useful as early predictors of cardiac toxicity in anthracycline-naïve patients receiving trastuzumab and/or lapatinib.
%K Brain natriuretic peptide
%K Cardiotoxicity
%K HER2 positive breast cancer
%K Lapatinib
%K Troponin T
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