RT Journal Article
T1 The cognitive and psychiatric subacute impairment in severe Covid-19.
A1 Serrano-Castro, Pedro J
A1 Garzon-Maldonado, Francisco J
A1 Casado-Naranjo, Ignacio
A1 Ollero-Ortiz, Angela
A1 Mínguez-Castellanos, Adolfo
A1 Iglesias-Espinosa, Mar
A1 Baena-Palomino, Pablo
A1 Sanchez-Sanchez, Violeta
A1 Sanchez-Perez, Rosa Maria
A1 Rubi-Callejon, Jose
A1 Estevez-Maria, Jose Carlos
A1 Galeano-Bilbao, Benito
A1 Romero-Imbroda, Jesus
A1 Sobrino, Beatriz
A1 Arrabal-Gomez, Carlos
A1 Oliver-Martos, Begoña
A1 Muñoz-Becerra, Luis
A1 Requena, Nerea
A1 Gonzalez Alvarez de Sotomayor, Maria Del Mar
A1 Estivill-Torrus, Guillermo
A1 Suarez, Juan
A1 Ciano-Petersen, Nicolas Lundahl
A1 Pons-Pons, Gracia
A1 Reyes-Bueno, Jose Antonio
A1 Cabezudo-Garcia, Pablo
A1 Aguilar-Castillo, Maria José
A1 De la Cruz Cosme, Carlos
A1 Duque-Holguera, Maria
A1 Cuartero-Rodriguez, Eva
A1 Vilches-Carrillo, Rosa María
A1 Carrera-Muñoz, Ismael
A1 Carnero-Pardo, Cristóbal
A1 Ramirez-Garcia, Teresa
A1 Oropesa, Juan Manuel
A1 Dominguez-Mayoral, Ana
A1 Pelaez-Viñas, Nazaret
A1 Valiente, Lucia
A1 de Fonseca, Fernando Rodríguez
K1 Central nervous system infections
K1 Cognitive neuroscience
K1 Diseases of the nervous system
K1 Dementia
K1 Neurodegenerative diseases
K1 Neuroimmunology
AB Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases.
PB Nature Publishing Group
YR 2022
FD 2022-02-21
LK http://hdl.handle.net/10668/19593
UL http://hdl.handle.net/10668/19593
LA en
NO Serrano-Castro PJ, Garzón-Maldonado FJ, Casado-Naranjo I, Ollero-Ortiz A, Mínguez-Castellanos A, Iglesias-Espinosa M, et al. The cognitive and psychiatric subacute impairment in severe Covid-19. Sci Rep. 2022 Mar 3;12(1):3563.
DS RISalud
RD Apr 11, 2025