RT Journal Article
T1 Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study
A1 Abilés, Jimena
A1 P de la Cruz, Antonio
A1 Castaño, José
A1 Rodríguez-Elvira, Manuel
A1 Aguayo, Eduardo
A1 Moreno-Torres, Rosario
A1 Llopis, Juan
A1 Aranda, Pilar
A1 Argüelles, Sandro
A1 Ayala, Antonio
A1 M de la Quintana, Alberto
A1 Planells, Elena M
K1 Adulto
K1 Anciano
K1 Anciano de 80 o más Años
K1 Antioxidantes
K1 Marcadores Biológicos
K1 Estudios de Cohortes
K1 Enfermedad Crítica
K1 Femenino
K1 Humanos
K1 Masculino
K1 Mediana Edad
K1 Oxidación-Reducción
K1 Estrés Oxidativo
K1 Especies de Oxígeno Reactivo
K1 Índice de Severidad de la Enfermedad
K1 Vitaminas
AB Introduction. Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Although ROS/RNS are constantly produced under normal circumstances, critical illness can drastically increase their production. These patients have reduced plasma and intracellular levels of antioxidants and free electron scavengers or cofactors, and decreased activity of the enzymatic system involved in ROS detoxification. The pro-oxidant/antioxidant balance is of functional relevance during critical illness because it is involved in the pathogenesis of multiple organ failure. In this study the objective was to evaluate the relation between oxidative stress in critically ill patients and antioxidant vitamin intake and severity of illness. Methods. Spectrophotometry was used to measure in plasma the total antioxidant capacity and levels of lipid peroxide, carbonyl group, total protein, bilirubin and uric acid at two time points: at intensive care unit (ICU) admission and on day seven. Daily diet records were kept and compliance with recommended dietary allowance (RDA) of antioxidant vitamins (A, C and E) was assessed. Results. Between admission and day seven in the ICU, significant increases in lipid peroxide and carbonyl group were associated with decreased antioxidant capacity and greater deterioration in Sequential Organ Failure Assessment score. There was significantly greater worsening in oxidative stress parameters in patients who received antioxidant vitamins at below 66% of RDA than in those who received antioxidant vitamins at above 66% of RDA. An antioxidant vitamin intake from 66% to 100% of RDA reduced the risk for worsening oxidative stress by 94% (ods ratio 0.06, 95% confidence interval 0.010 to 0.39), regardless of change in severity of illness (Sequential Organ Failure Assessment score). Conclusion. The critical condition of patients admitted to the ICU is associated with worsening oxidative stress. Intake of antioxidant vitamins below 66% of RDA and alteration in endogenous levels of substances with antioxidant capacity are related to redox imbalance in critical ill patients. Therefore, intake of antioxidant vitamins should be carefully monitored so that it is as close as possible to RDA.
PB BioMed Central
SN 1364-8535
YR 2006
FD 2006-10-13
LK http://hdl.handle.net/10668/442
UL http://hdl.handle.net/10668/442
LA en
NO Abilés J, P de la Cruz A, Castaño J, Rodríguez-Elvira M,  Aguayo E, Moreno-Torres R et al.  Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study.Crit Care. 2006;10(5):R146.
DS RISalud
RD Apr 18, 2025