RT Journal Article
T1 Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population.
A1 Cobos-Palacios, Lidia
A1 Ruiz-Moreno, Maria Isabel
A1 Vilches-Perez, Alberto
A1 Vargas-Candela, Antonio
A1 Muñoz-Ubeda, Monica
A1 Benitez Porres, Javier
A1 Navarro-Sanz, Ana
A1 Lopez-Carmona, Maria Dolores
A1 Sanz-Canovas, Jaime
A1 Perez-Belmonte, Luis M
A1 Mancebo-Sevilla, Juan Jose
A1 Gomez-Huelgas, Ricardo
A1 Bernal-Lopez, Maria Rosa
K1 Adipokines
K1 Adiponectin
K1 Aged, 80 and over
K1 Biomarkers
K1 C-Reactive Protein
AB Obesity is linked to elevated levels of inflammatory serum markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFa). Adiponectin and resistin are adipokines related to obesity. It has been described that adipose tissue presents a high production and secretion of these diverse pro-inflammatory molecules, which may have local effects on the physiology of fat cells as well as systemic effects on other organs. Our aim was to evaluate the impact that lifestyle modifications, by following a Mediterranean Diet (MedDiet) program and physical activity (PA) training, would have on inflammatory biomarkers and adipokine profile in a Metabolically Healthy Obese (MHO) elderly population from Malaga (Andalusia, Spain). Subjects aged ≥65 years (65 to 87 years old) with obesity (BMI ≥30 kg/m2) were included in this study if they met ≤1 of the following criteria: systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥ 85 mmHg; triglycerides ≥150 mg/dL; HDL-C  166 MHO elderly subjects, 40 (24.1%) male and 126 (75.9%) female (p  Healthy aging is a multifactorial biological process in which lifestyle is essential. The presence of obesity in elderly metabolically healthy population is not a problem necessarily. Elderly MHO population who eat a MedDiet and practice regularly PA are capable to modulate their production of inflammatory cytokines (CRP, IL-6, TNFa) and adipokines profile (adiponectin, resistin), preventing other metabolic disorders.
PB Public Library of Science
YR 2022
FD 2022-06-09
LK http://hdl.handle.net/10668/20423
UL http://hdl.handle.net/10668/20423
LA en
NO Cobos-Palacios L, Ruiz-Moreno MI, Vilches-Perez A, Vargas-Candela A, Muñoz-Úbeda M, Benítez Porres J, et al. Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population. PLoS One. 2022 Jun 9;17(6):e0265362
DS RISalud
RD Apr 28, 2025