RT Journal Article
T1 Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach
A1 Moya-García, Aurelio A.
A1 Pino-Ángeles, Almudena
A1 Sánchez-Jiménez, Francisca
A1 Urdiales, José Luis
A1 Medina, Miguel Ángel
K1 Metabolic remodelling
K1 Angiogenesis
K1 Systems biology
K1 Histamine
K1 Cancer
K1 Metabolism
K1 Biología de sistemas
K1 Histamina
K1 Neoplasias
K1 Homeostasis
K1 Metabolismo
AB Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the "histamine system" with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances.
PB MDPI
YR 2021
FD 2021-03-11
LK http://hdl.handle.net/10668/4090
UL http://hdl.handle.net/10668/4090
LA en
NO Moya-García AA, Pino-Ángeles A, Sánchez-Jiménez F, Urdiales JL, Medina MÁ. Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach. Biomolecules. 2021 Mar 11;11(3):415.
DS RISalud
RD Apr 14, 2025