RT Journal Article
T1 Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration.
A1 Baena, J M
A1 Jimenez, G
A1 Lopez-Ruiz, E
A1 Antich, C
A1 Griñan-Lison, C
A1 Peran, M
A1 Galvez-Martin, P
A1 Marchal, J A
K1 Bioprinting
K1 additive manufacturing
K1 cartilage
K1 engineering
K1 regenerative medicine
K1 scaffold
AB 3D bioprinting represents a novel advance in the area of regenerative biomedicine and tissue engineering for the treatment of different pathologies, among which are those related to cartilage. Currently, the use of different thermoplastic polymers, such as PLA or PCL, for bioprinting processes presents an important limitation: the high temperatures that are required for extrusion affect the cell viability and the final characteristics of the construct. In this work, we present a novel bioprinting process called volume-by-volume (VbV) that allows us to preserve cell viability after bioprinting. This procedure allows cell injection at a safe thermoplastic temperature, and also allows the cells to be deposited in the desired areas of the construct, without the limitations caused by high temperatures. The VbV process could make it easier to bring 3D bioprinting into the clinic, allowing the generation of tissue constructs with polymers that are currently approved for clinical use.
PB Frontiers Media SA
YR 2019
FD 2019-01-10
LK http://hdl.handle.net/10668/13409
UL http://hdl.handle.net/10668/13409
LA en
NO Baena JM, Jiménez G, López-Ruiz E, Antich C, Griñán-Lisón C, et al. Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration. Exp Biol Med (Maywood). 2019 Jan;244(1):13-21.
DS RISalud
RD Apr 5, 2025