TY  - JOUR
AU  - Nguyen, Tra Ly
AU  - Nokin, Marie-Julie
AU  - Terés, Silvia
AU  - Tomé, Mercedes
AU  - Bodineau, Clément
AU  - Galmar, Oriane
AU  - Pasquet, Jean-Max
AU  - Rousseau, Benoit
AU  - van Liempd, Sebastian
AU  - Falcon-Perez, Juan Manuel
AU  - Richard, Elodie
AU  - Muzotte, Elodie
AU  - Rezvani, Hamid-Reza
AU  - Priault, Muriel
AU  - Bouchecareilh, Marion
AU  - Redonnet-Vernhet, Isabelle
AU  - Calvo, Julien
AU  - Uzan, Benjamin
AU  - Pflumio, Françoise
AU  - Fuentes, Patricia
AU  - Toribio, Maria L.
AU  - Khatib, Abdel-Majid
AU  - Soubeyran, Pierre
AU  - Murdoch, Piedad del Socorro
AU  - Durán, Raúl V.
PY  - 2020
DO  - 10.1002/1878-0261.12877
SN  - 1574-7891
UR  - http://hdl.handle.net/10668/4584
T2  - Molecular Oncology
AB  - The cellular receptor Notch1 is a central regulator of T-cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T-cell acute lymphoblastic leukemia (T-ALL). However, strategies targeting Notch1 signaling...
LA  - en
PB  - Wiley
KW  - Glutamine
KW  - Glutamine synthetase
KW  - Metabolic addiction
KW  - mTORC1
KW  - Notch1
KW  - T-cell acute lymphoblastic leukemia
KW  - Downregulation
KW  - Cell line
KW  - Glutamina
KW  - Glutamato-amoníaco ligasa
KW  - Metabolismo
KW  - Diana mecanicista del complejo 1 de la rapamicina
KW  - Receptor Notch1
KW  - Leucemia-linfoma linfoblástico de células T precursoras
KW  - Regulación hacia abajo
KW  - Línea celular
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Down-Regulation
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Enzymologic
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic::Gene Expression Regulation, Leukemic
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Carbon-Nitrogen Ligases::Amide Synthases::Glutamate-Ammonia Ligase
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Basic::Glutamine
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred NOD
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Transgenic
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Notch::Receptor, Notch1
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Up-Regulation
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
TI  - Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia
TY  - research article
ER  -