RT Journal Article
T1 Usefulness of optic nerve ultrasound to predict clinical progression in multiple sclerosis.
T2 Utilidad de la ecografía de nervio óptico como predictor de progresión en esclerosis múltiple.
A1 Pérez Sánchez, S
A1 Eichau Madueño, S
A1 Rus Hidalgo, M
A1 Domínguez Mayoral, A M
A1 Vilches-Arenas, A
A1 Navarro Mascarell, G
A1 Izquierdo, G
K1 Echography
K1 Ecografía
K1 Esclerosis múltiple
K1 Multiple sclerosis
K1 Nervio óptico
K1 Optic nerve
K1 Progresión
K1 Progression
AB Progressive neuronal and axonal loss are considered the main causes of disability in patients with multiple sclerosis (MS). The disease frequently involves the visual system; the accessibility of the system for several functional and structural tests has made it a model for the in vivo study of MS pathogenesis. Orbital ultrasound is a non-invasive technique that enables various structures of the orbit, including the optic nerve, to be evaluated in real time. We conducted an observational, ambispective study of MS patients. Disease progression data were collected. Orbital ultrasound was performed on all patients, with power set according to the 'as low as reasonably achievable' (ALARA) principle. Optical coherence tomography (OCT) data were also collected for those patients who underwent the procedure. Statistical analysis was conducted using SPSS version 22.0. Disease progression was significantly correlated with ultrasound findings (P=.041 for the right eye and P=.037 for the left eye) and with Expanded Disability Status Scale (EDSS) score at the end of the follow-up period (P=.07 for the right eye and P=.043 for the left eye). No statistically significant differences were found with relation to relapses or other clinical variables. Ultrasound measurement of optic nerve diameter constitutes a useful, predictive factor for the evaluation of patients with MS. Smaller diameters are associated with poor clinical progression and greater disability (measured by EDSS).
YR 2018
FD 2018-03-21
LK http://hdl.handle.net/10668/12272
UL http://hdl.handle.net/10668/12272
LA en
LA es
DS RISalud
RD Apr 9, 2025