RT Journal Article
T1 Telomerase RNA Component Genetic Variants Interact With the Mediterranean Diet Modifying the Inflammatory Status and its Relationship With Aging: CORDIOPREV Study.
A1 Gomez-Delgado, Francisco
A1 Delgado-Lista, Javier
A1 Lopez-Moreno, Javier
A1 Rangel-Zuñiga, Oriol Alberto
A1 Alcala-Diaz, Juan Francisco
A1 Leon-Acuña, Ana
A1 Corina, Andreea
A1 Yubero-Serrano, Elena
A1 Torres-Peña, Jose David
A1 Camargo, Antonio
A1 Garcia-Rios, Antonio
A1 Caballero, Javier
A1 Castaño, Justo
A1 Ordovas, Jose M
A1 Lopez-Miranda, Jose
A1 Perez-Martinez, Pablo
K1 Polymerase chain reaction
K1 Polymorphism, single nucleotide
K1 RNA
K1 Randomized controlled trials as topic
K1 Secondary prevention
K1 Spain
K1 Telomerase
AB Leukocyte telomere length (LTL) attrition has been associated with age-related diseases. Telomerase RNA Component (TERC) genetic variants have been associated with LTL; whereas fatty acids (FAs) can interact with genetic factors and influence in aging. We explore whether variability at the TERC gene locus interacts with FA profile and two healthy diets (low-fat diet vs Mediterranean diet [MedDiet]) modulating LTL, glucose metabolism, and inflammation status in coronary heart disease (CHD) patients. Inflammation status (high-sensitivity C-reactive protein [hsCRP], glucose metabolism-glucose, insulin, and glycated hemoglobin [HbA1c], and homeostasis model assessment of insulin resistance [HOMA-IR]), LTL, FAs, and single nucleotide polymorphisms (SNPs) of the TERC gene (rs12696304, rs16847897, and rs3772190) were determined in 1,002 patients from the CORDIOPREV study (NCT00924937). We report an interaction of the TERC rs12696304 SNP with monounsaturated fatty acid (MUFA) affecting LTL (p interaction = .01) and hsCRP (p interaction = .03). Among individuals with MUFA levels above the median, CC individuals showed higher LTL and lower hsCRP than G-allele carriers. Moreover, MedDiet interacted with TERC rs12696304 SNP (p interaction = .03). Specifically, CC individuals displayed a greater decrease in hsCRP than G-allele carriers. These results were not adjusted for multiple statistical testing and p less than .05 was considered significant. Our findings suggest that the TERC rs12696304 SNP interacts with MUFA improving inflammation status and telomere attrition related with CHD. Moreover, the MedDiet intervention improves the inflammatory profile in CC individuals compared with the G-allele carriers. These interactions could provide a right strategy for personalized nutrition in CHD patients.
PB Oxford University Press
YR 2016
FD 2016-09-13
LK http://hdl.handle.net/10668/10508
UL http://hdl.handle.net/10668/10508
LA en
NO Gomez-Delgado F, Delgado-Lista J, Lopez-Moreno J, Rangel-Zuñiga OA, Alcala-Diaz JF, Leon-Acuña A, et al. Telomerase RNA Component Genetic Variants Interact With the Mediterranean Diet Modifying the Inflammatory Status and its Relationship With Aging: CORDIOPREV Study. J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):327-332
DS RISalud
RD Apr 9, 2025