RT Journal Article
T1 Relationship between headaches and tinnitus in a Swedish study.
A1 Lugo, Alessandra
A1 Edvall, Niklas K
A1 Lazar, Andra
A1 Mehraei, Golbarg
A1 Lopez-Escamez, Jose-Antonio
A1 Bulla, Jan
A1 Uhlen, Inger
A1 Canlon, Barbara
A1 Gallus, Silvano
A1 Cederroth, Christopher R
K1 Auditory system
K1 Headache
K1 Risk factors
AB The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.
PB Nature Publishing Group
YR 2020
FD 2020-05-04
LK http://hdl.handle.net/10668/15623
UL http://hdl.handle.net/10668/15623
LA en
NO Lugo A, Edvall NK, Lazar A, Mehraei G, Lopez-Escamez JA, Bulla J, et al. Relationship between headaches and tinnitus in a Swedish study. Sci Rep. 2020 May 22;10(1):8494.
NO We gratefully acknowledge the support and generosity of Nancy Pedersen, head of LifeGene. This study was funded by the GENDER-NET Co-Plus Fund (GNP-182, to CRC, SG, JALE and JB). In addition, CRC has received research funding from Decibel Therapeutics, Inc., Svenska Läkaresällskapet (SLS-779681), Tysta Skolan, Hörselforskningsfonden (#503), the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 72204655. BC has received funding from the Swedish Medical Research Council K2014-99×-22478-01-3, Karolinska Institutet and Tysta Skolan. SG is an Honorary Associate Professor at the University of Nottingham, School of Medicine. Open access funding provided by Karolinska Institute.
DS RISalud
RD Apr 14, 2025