RT Journal Article
T1 Evaluation of two HbA1c point-of-care analyzers.
A1 Sánchez-Mora, Catalina
A1 Rodríguez-Oliva, Manuel S
A1 Fernández-Riejos, Patricia
A1 Mateo, Joaquín
A1 Polo-Padillo, Juan
A1 Goberna, Raimundo
A1 Sánchez-Margalet, Víctor
K1 diabetes
K1 evaluation
K1 HbA1c
K1 point-of-care testing
K1 interference
K1 Análisis químico de la sangre
K1 Cromatografía líquida de Alta Presión
K1 Cromatografía por intercambio Iónico
K1 Hemoglobina A glucosilada
AB BACKGROUNDMeasurement of HbA1c is the most important parameter to assess glycemic control in diabetic patients. Different point-of-care devices for HbA1c are available. The aim of this study was to evaluate two point-of-care testing (POCT) analyzers (DCA Vantage from Siemens and Afinion from Axis-Shield). We studied the bias and precision as well as interference from carbamylated hemoglobin.METHODSBias of the POCT analyzers was obtained by measuring 53 blood samples from diabetic patients with a wide range of HbA1c, 4%-14% (20-130 mmol/mol), and comparing the results with those obtained by the laboratory method: HPLC HA 8160 Menarini. Precision was performed by 20 successive determinations of two samples with low 4.2% (22 mmol/mol) and high 9.5% (80 mmol/mol) HbA1c values. The possible interference from carbamylated hemoglobin was studied using 25 samples from patients with chronic renal failure.RESULTSThe means of the differences between measurements performed by each POCT analyzer and the laboratory method (95% confidence interval) were: 0.28% (p<0.005) (0.10-0.44) for DCA and 0.27% (p<0.001) (0.19-0.35) for Afinion. Correlation coefficients were: r=0.973 for DCA, and r=0.991 for Afinion. The mean bias observed by using samples from chronic renal failure patients were 0.2 (range -0.4, 0.4) for DCA and 0.2 (-0.2, 0.5) for Afinion. Imprecision results were: CV=3.1% (high HbA1c) and 2.97% (low HbA1c) for DCA, CV=1.95% (high HbA1c) and 2.66% (low HbA1c) for Afinion.CONCLUSIONSBoth POCT analyzers for HbA1c show good correlation with the laboratory method and acceptable precision.
PB De Gruyter
SN 1434-6621
YR 2011
FD 2011-04
LK http://hdl.handle.net/10668/2056
UL http://hdl.handle.net/10668/2056
LA en
NO Sánchez-Mora C, S Rodríguez-Oliva M, Fernández-Riejos P, Mateo J, Polo-Padillo J, Goberna R, et al. Evaluation of two HbA1c point-of-care analyzers. Clin. Chem. Lab. Med.. 2011 Apr; 49(4):653-7
NO Journal Article;
DS RISalud
RD Apr 19, 2025