RT Journal Article
T1 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
A1 Mullins, Niamh
A1 Bigdeli, Tim B
A1 Borglum, Anders D
A1 Coleman, Jonathan R I
A1 Demontis, Ditte
A1 Mehta, Divya
A1 Power, Robert A
A1 Ripke, Stephan
A1 Stahl, Eli A
A1 Starnawska, Anna
A1 Anjorin, Adebayo
A1 M.R.C.Psych, 
A1 Corvin, Aiden
A1 Sanders, Alan R
A1 Forstner, Andreas J
A1 Reif, Andreas
A1 Koller, Anna C
A1 Swiatkowska, Beata
A1 Baune, Bernhard T
A1 Müller-Myhsok, Bertram
A1 Penninx, Brenda W J H
A1 Pato, Carlos
A1 Zai, Clement
A1 Rujescu, Dan
A1 Hougaard, David M
A1 Quested, Digby
A1 Levinson, Douglas F
A1 Binder, Elisabeth B
A1 Byrne, Enda M
A1 Agerbo, Esben
A1 Dr.Med.Sc, 
A1 Streit, Fabian
A1 Mayoral, Fermin
A1 Bellivier, Frank
A1 Degenhardt, Franziska
A1 Breen, Gerome
A1 Morken, Gunnar
A1 Turecki, Gustavo
A1 Rouleau, Guy A
A1 Grabe, Hans J
A1 Volzke, Henry
A1 Jones, Ian
A1 Giegling, Ina
A1 Agartz, Ingrid
A1 Melle, Ingrid
A1 Lawrence, Jacob
A1 M.R.C.Psych, 
A1 Walters, James T R
A1 Strohmaier, Jana
A1 Shi, Jianxin
A1 Hauser, Joanna
A1 Biernacka, Joanna M
A1 Vincent, John B
A1 Kelsoe, John
A1 Strauss, John S
A1 Lissowska, Jolanta
A1 Pimm, Jonathan
A1 M.R.C.Psych, 
A1 Smoller, Jordan W
A1 Guzman-Parra, Jose
A1 Berger, Klaus
A1 Scott, Laura J
A1 Jones, Lisa A
A1 Azevedo, M Helena
A1 Trzaskowski, Maciej
A1 Kogevinas, Manolis
A1 Rietschel, Marcella
A1 Boks, Marco
A1 Ising, Marcus
A1 Grigoroiu-Serbanescu, Maria
A1 Hamshere, Marian L
A1 Leboyer, Marion
A1 Frye, Mark
A1 Nöthen, Markus M
A1 Alda, Martin
A1 Preisig, Martin
A1 Nordentoft, Merete
A1 Boehnke, Michael
A1 O'Donovan, Michael C
A1 Owen, Michael J
A1 Pato, Michele T
A1 Renteria, Miguel E
A1 Budde, Monika
A1 Dipl.-Psych, 
A1 Weissman, Myrna M
A1 Wray, Naomi R
A1 Bass, Nicholas
A1 M.R.C.Psych, 
A1 Craddock, Nicholas
A1 Smeland, Olav B
A1 Andreassen, Ole A
A1 Mors, Ole
A1 Gejman, Pablo V
A1 Sklar, Pamela
A1 McGrath, Patrick
A1 Hoffmann, Per
A1 McGuffin, Peter
A1 Lee, Phil H
A1 Mortensen, Preben Bo
A1 Kahn, Rene S
A1 Ophoff, Roel A
A1 Adolfsson, Rolf
A1 Van-der-Auwera, Sandra
A1 Djurovic, Srdjan
A1 Kloiber, Stefan
A1 Heilmann-Heimbach, Stefanie
A1 Jamain, Stéphane
A1 Hamilton, Steven P
A1 McElroy, Susan L
A1 Lucae, Susanne
A1 Cichon, Sven
A1 Schulze, Thomas G
A1 Hansen, Thomas
A1 Werge, Thomas
A1 Air, Tracy M
A1 Nimgaonkar, Vishwajit
A1 Appadurai, Vivek
A1 Cahn, Wiepke
A1 Milaneschi, Yuri
A1 Fanous, Ayman H
A1 Kendler, Kenneth S
A1 McQuillin, Andrew
A1 Lewis, Cathryn M
K1 Genome-Wide Association Study
K1 Mood Disorders
K1 Polygenic Risk Scoring
K1 Psychiatric Genomics Consortium
K1 Schizophrenia
K1 Suicide
AB More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2=0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2=0.40%). This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.
PB American Psychiatric Association Publishing
YR 2019
FD 2019-06-05
LK http://hdl.handle.net/10668/14076
UL http://hdl.handle.net/10668/14076
LA en
NO Mullins N, Bigdeli TB, Børglum AD, Coleman JRI, Demontis D, Mehta D, et al. GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores. Am J Psychiatry. 2019 Aug 1;176(8):651-660
DS RISalud
RD Apr 7, 2025