RT Journal Article
T1 COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence.
A1 Tsatsakis, Aristidis
A1 Petrakis, Demetrious
A1 Nikolouzakis, Taxiarchis Konstantinos
A1 Docea, Anca Oana
A1 Calina, Daniela
A1 Vinceti, Marco
A1 Goumenou, Marina
A1 Kostoff, Ronald N
A1 Mamoulakis, Charalampos
A1 Aschner, Michael
A1 Hernández, Antonio F
K1 COVID-19
K1 Chronic diseases
K1 Coronavirus
K1 Epidemic
K1 Immune deficiency
K1 Pandemic
K1 Pollutants
K1 SARS-CoV-2
K1 Xenobiotics
AB Occupational, residential, dietary and environmental exposures to mixtures of synthetic anthropogenic chemicals after World War II have a strong relationship with the increase of chronic diseases, health cost and environmental pollution. The link between environment and immunity is particularly intriguing as it is known that chemicals and drugs can cause immunotoxicity (e.g., allergies and autoimmune diseases). In this review, we emphasize the relationship between long-term exposure to xenobiotic mixtures and immune deficiency inherent to chronic diseases and epidemics/pandemics. We also address the immunotoxicologic risk of vulnerable groups, taking into account biochemical and biophysical properties of SARS-CoV-2 and its immunopathological implications. We particularly underline the common mechanisms by which xenobiotics and SARS-CoV-2 act at the cellular and molecular level. We discuss how long-term exposure to thousand chemicals in mixtures, mostly fossil fuel derivatives, exposure toparticle matters, metals, ultraviolet (UV)-B radiation, ionizing radiation and lifestyle contribute to immunodeficiency observed in the contemporary pandemic, such as COVID-19, and thus threaten global public health, human prosperity and achievements, and global economy. Finally, we propose metrics which are needed to address the diverse health effects of anthropogenic COVID-19 crisis at present and those required to prevent similar future pandemics.
YR 2020
FD 2020-05-11
LK http://hdl.handle.net/10668/15609
UL http://hdl.handle.net/10668/15609
LA en
DS RISalud
RD Apr 9, 2025