RT Journal Article
T1 Morphofunctional and Molecular Assessment of Nutritional Status in Head and Neck Cancer Patients Undergoing Systemic Treatment: Role of Inflammasome in Clinical Nutrition.
A1 Leon-Idougourram, Soraya
A1 Perez-Gomez, Jesus M
A1 Muñoz Jimenez, Concepcion
A1 L-Lopez, Fernando
A1 Manzano Garcia, Gregorio
A1 Molina Puertas, Maria Jose
A1 Herman-Sanchez, Natalia
A1 Alonso-Echague, Rosario
A1 Calañas Continente, Alfonso
A1 Galvez Moreno, Maria Angeles
A1 Luque, Raul M
A1 Gahete, Manuel D
A1 Herrera-Martinez, Aura D
K1 Comorbidities
K1 Head and neck cancer
K1 Malnutrition
K1 Sarcopenia
AB Malnutrition in patients with head and neck cancer is frequent, multifactorial and widely associated with clinical evolution and prognosis. Accurate nutritional assessments allow for early identification of patients at risk of malnutrition in order to start nutritional support and prevent sarcopenia. We aimed to perform a novel morphofunctional nutritional evaluation and explore changes in inflammasome-machinery components in 45 patients with head and neck cancer who are undergoing systemic treatment. To this aim, an epidemiological/clinical/anthropometric/biochemical evaluation was performed. Serum RCP, IL6 and molecular expression of inflammasome-components and inflammatory-associated factors (NOD-like-receptors, inflammasome-activation-components, cytokines and inflammation/apoptosis-related components, cell-cycle and DNA-damage regulators) were evaluated in peripheral-blood mononuclear-cells (PBMCs). Clinical-molecular correlations/associations were analyzed. Coherent and complementary information was obtained in the morphofunctional nutritional assessment of the patients when bioimpedance, anthropometric and ultrasound data were analyzed. These factors were also correlated with different biochemical and molecular parameters, revealing the complementary aspect of the whole evaluation. Serum reactive C protein (RCP) and IL6 were the most reliable parameters for determining patients with decreased standardized phase angle, which is associated with increased mortality in patients with solid malignancies. Several inflammasome-components were dysregulated in patients with malnutrition, decreased phase angle and dependency grade or increased circulating inflammation markers. A molecular fingerprint based on gene-expression of certain inflammasome factors (p27/CCL2/ASC) in PBMCs accurately differentiated patients with and without malnutrition. In conclusion, malnutrition induces a profound alteration in the gene-expression pattern of inflammasome-machinery components in PBMCs. A comprehensive nutritional assessment including novel morphofunctional techniques and molecular markers allows a broad characterization of the nutritional status in cancer patients. Profile of certain inflammasome-components should be further studied as potential targets for nutrition-focused treatment strategies in cancer patients.
PB MDPI
SN 2072-6694
YR 2022
FD 2022-01-10
LK http://hdl.handle.net/10668/20869
UL http://hdl.handle.net/10668/20869
LA en
NO León-Idougourram S, Pérez-Gómez JM, Muñoz Jiménez C, L-López F, Manzano García G, Molina Puertas MJ, et al. Morphofunctional and Molecular Assessment of Nutritional Status in Head and Neck Cancer Patients Undergoing Systemic Treatment: Role of Inflammasome in Clinical Nutrition. Cancers (Basel). 2022 Jan 19;14(3):494
DS RISalud
RD Apr 6, 2025