RT Journal Article
T1 Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
A1 Cardenas, Casimiro
A1 Antonio Torres-Vargas, Jose
A1 Cardenas-Valdivia, Abel
A1 Jurado, Nuria
A1 Quesada, Ana R.
A1 Garcia-Caballero, Melissa
A1 Martinez-Poveda, Beatriz
A1 Angel Medina, Miguel
K1 Ultra-high-performance liquid
K1 chromatography-high-resolution mass spec-trometry(UHPLC-HRMS)
K1 Annona muricata
K1 Graviola
K1 Soursop
K1 Angiogenesis
K1 Breast-cancer cells
K1 In-vitro
K1 Ring acetogenins
K1 Ethanol extract
K1 L. annonaceae
K1 Fruit extract
K1 Leaves
K1 Graviola
K1 Antioxidant
K1 Identification
AB The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
PB Elsevier france-editions scientifiques medicales elsevier
SN 0753-3322
YR 2021
FD 2021-10-06
LK https://hdl.handle.net/10668/27565
UL https://hdl.handle.net/10668/27565
LA en
DS RISalud
RD Apr 17, 2025