TY - JOUR AU - Pothlichet, Julien AU - Rose, Thierry AU - Bugault, Florence AU - Jeammet, Louise AU - Meola, Annalisa AU - Haouz, Ahmed AU - Saul, Frederick AU - Geny, David AU - Alcami, José AU - Ruiz-Mateos, Ezequiel AU - Teyton, Luc AU - Lambeau, Gérard AU - Thèze, Jacques PY - 2020 DO - 10.1172/JCI131842 UR - http://hdl.handle.net/10668/15607 T2 - The Journal of clinical investigation AB - The precise mechanism leading to profound immunodeficiency of HIV-infected patients is still only partially understood. Here, we show that more than 80% of CD4+ T cells from HIV-infected patients have morphological abnormalities. Their membranes... LA - en KW - AIDS/HIV KW - Cytokines KW - Immunology KW - Lipid rafts KW - T cells KW - CD4-Positive T-Lymphocytes KW - Clonal Anergy KW - Cytokines KW - Female KW - Group IB Phospholipases A2 KW - HIV Infections KW - HIV-1 KW - Humans KW - Lymphopenia KW - Male TI - PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients. TY - research article VL - 130 ER -