RT Journal Article
T1 Identification of miRSNPs associated with the risk of multiple myeloma.
A1 Macauda, Angelica
A1 Calvetti, Diego
A1 Maccari, Giuseppe
A1 Hemminki, Kari
A1 Försti, Asta
A1 Goldschmidt, Hartmut
A1 Weinhold, Niels
A1 Houlston, Richard
A1 Andersen, Vibeke
A1 Vogel, Ulla
A1 Buda, Gabriele
A1 Varkonyi, Judit
A1 Sureda, Anna
A1 Martinez Lopez, Joaquin
A1 Watek, Marzena
A1 Butrym, Aleksandra
A1 Sarasquete, Maria Eugenia
A1 Dudziński, Marek
A1 Jurczyszyn, Artur
A1 Druzd-Sitek, Agnieszka
A1 Kruszewski, Marcin
A1 Subocz, Edyta
A1 Petrini, Mario
A1 Iskierka-Jażdżewska, Elzbieta
A1 Raźny, Malgorzata
A1 Szombath, Gergely
A1 Marques, Herlander
A1 Zawirska, Daria
A1 Chraniuk, Dominik
A1 Halka, Janusz
A1 Hove Jacobsen, Svend Erik
A1 Mazur, Grzegorz
A1 García Sanz, Ramón
A1 Dumontet, Charles
A1 Moreno, Victor
A1 Stępień, Anna
A1 Beider, Katia
A1 Pelosini, Matteo
A1 Manuel Reis, Rui
A1 Krawczyk-Kulis, Malgorzata
A1 Rymko, Marcin
A1 Avet-Loiseau, Hervé
A1 Lesueur, Fabienne
A1 Grząśko, Norbert
A1 Ostrovsky, Olga
A1 Jamroziak, Krzysztof
A1 Vangsted, Annette J
A1 Jerez, Andrés
A1 Tomczak, Waldemar
A1 Zaucha, Jan Maciej
A1 Kadar, Katalin
A1 Sainz, Juan
A1 Nagler, Arnon
A1 Landi, Stefano
A1 Gemignani, Federica
A1 Canzian, Federico
K1 Genetic susceptibility
K1 Multiple myeloma
K1 SNP
K1 miRNA
AB Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility to the disease. SNPs within miRNA-binding sites in target genes (miRSNPs) may alter the strength of miRNA-mRNA interactions, thus deregulating protein expression. MiRSNPs are known to be associated with risk of various types of cancer, but they have never been investigated in MM. We performed an in silico genome-wide search for miRSNPs predicted to alter binding of miRNAs to their target sequences. We selected 12 miRSNPs and tested their association with MM risk. Our study population consisted of 1,832 controls and 2,894 MM cases recruited from seven European countries and Israel in the context of the IMMEnSE (International Multiple Myeloma rESEarch) consortium. In this population two SNPs showed an association with p 
YR 2016
FD 2016-11-09
LK http://hdl.handle.net/10668/10520
UL http://hdl.handle.net/10668/10520
LA en
DS RISalud
RD Jul 29, 2025