RT Journal Article
T1 Aversive memory formation in humans involves an amygdala-hippocampus phase code.
A1 Costa, Manuela
A1 Lozano-Soldevilla, Diego
A1 Gil-Nagel, Antonio
A1 Toledano, Rafael
A1 Oehrn, Carina R
A1 Kunz, Lukas
A1 Yebra, Mar
A1 Mendez-Bertolo, Costantino
A1 Stieglitz, Lennart
A1 Sarnthein, Johannes
A1 Axmacher, Nikolai
A1 Moratti, Stephan
A1 Strange, Bryan A
K1 Brain
K1 Memory disorders
K1 Cognition
K1 Hippocampus
K1 Mental disorders
AB Memory for aversive events is central to survival but can become maladaptive in psychiatric disorders. Memory enhancement for emotional events is thought to depend on amygdala modulation of hippocampal activity. However, the neural dynamics of amygdala-hippocampal communication during emotional memory encoding remain unknown. Using simultaneous intracranial recordings from both structures in human patients, here we show that successful emotional memory encoding depends on the amygdala theta phase to which hippocampal gamma activity and neuronal firing couple. The phase difference between subsequently remembered vs. not-remembered emotional stimuli translates to a time period that enables lagged coherence between amygdala and downstream hippocampal gamma. These results reveal a mechanism whereby amygdala theta phase coordinates transient amygdala -hippocampal gamma coherence to facilitate aversive memory encoding. Pacing of lagged gamma coherence via amygdala theta phase may represent a general mechanism through which the amygdala relays emotional content to distant brain regions to modulate other aspects of cognition, such as attention and decision-making.
PB Nature Publishing Group
YR 2022
FD 2022-10-05
LK http://hdl.handle.net/10668/19547
UL http://hdl.handle.net/10668/19547
LA en
NO Costa M, Lozano-Soldevilla D, Gil-Nagel A, Toledano R, Oehrn CR, Kunz L, et al. Aversive memory formation in humans involves an amygdala-hippocampus phase code. Nat Commun. 2022 Oct 27;13(1):6403
NO This project has received funding from the European Research Council(ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC-2018-COG 819814) and by the Swiss National ScienceFoundation (funded by SNSF 204651 to J.S.). M.C. was supported by theComunidad de Madrid, Ayudas para la contratación de investigadorespredoctorales e investigadores postdoctorales cofinanciadas por FondoSocial Europeo a través del Programa Operativo de Empleo Juvenil y laIniciativa de Empleo Juvenil (YEI) (PEJD-2017-POST/BMD-4763). L.K. wassupported by the German Research Foundation (DFG; KU 4060/1-1). Wethank the electroencephalography technicians at the Hospital RuberInternacional and the Swiss Epilepsy Center, as well as Isabel MontónQuesada and Linda Zhang for technical assistance. We thank Dr. RufinVanRullen for providing helpful comments about the rationale behindthe phase opposition metrics.
DS RISalud
RD Apr 13, 2025