TY - JOUR AU - Sánchez-Ceinos, Julia AU - Guzmán-Ruiz, Rocío AU - Rangel-Zúñiga, Oriol Alberto AU - López-Alcalá, Jaime AU - Moreno-Caño, Elena AU - Del Río-Moreno, Mercedes AU - Romero-Cabrera, Juan Luis AU - Pérez-Martínez, Pablo AU - Maymo-Masip, Elsa AU - Vendrell, Joan AU - Fernández-Veledo, Sonia AU - Fernández-Real, José Manuel AU - Laurencikiene, Jurga AU - Rydén, Mikael AU - Membrives, Antonio AU - Luque, Raul M. AU - López-Miranda, José AU - Malagón, María M. PY - 2021 DO - 10.7554/eLife.65996 UR - http://hdl.handle.net/10668/4480 T2 - eLife AB - Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the... LA - en PB - eLife Sciences Publications KW - mRNA KW - Proteostasis KW - Adipocytes KW - Obesity KW - Metabolic disease KW - Tissue expansion KW - ARN mensajero KW - Adipocitos KW - Obesidad KW - Enfermedades metabólicas KW - Expansión de tejido KW - Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Adipocytes KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Adipogenesis KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation KW - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Proteostasis Deficiencies KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Reconstructive Surgical Procedures::Tissue Expansion KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases TI - Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease TY - research article ER -