RT Journal Article
T1 Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes
A1 López, Escarlata
A1 Guerrero, Rosario
A1 Núñez, Maria I
A1 Moral, Rosario del
A1 Villalobos, Mercedes
A1 Martínez-Galán, Joaquina
A1 Valenzuela, Maria T
A1 Muñoz-Gámez, José A
A1 Oliver, Francisco J
A1 Martín-Oliva, David
A1 Ruiz de Almodóvar, José Mariano
K1 Braquiterapia
K1 Neoplasias de la Mama
K1 Radioisótopos de Cobalto
K1 Daño del ADN
K1 DNA, Neoplasm
K1 Fraccionamiento de la Dosis
K1 Femenino
K1 Estudios de Seguimiento
K1 Radioisótopos de Iridio
K1 Linfocitos
K1 Aceleradores de Partículas
K1 Radioisótopos de Iridio
K1 Factores de Tiempo
AB INTRODUCTIONRadiotherapy outcomes might be further improved by a greater understanding of the individual variations in normal tissue reactions that determine tolerance. Most published studies on radiation toxicity have been performed retrospectively. Our prospective study was launched in 1996 to measure the in vitro radiosensitivity of peripheral blood lymphocytes before treatment with radical radiotherapy in patients with breast cancer, and to assess the early and the late radiation skin side effects in the same group of patients. We prospectively recruited consecutive breast cancer patients receiving radiation therapy after breast surgery. To evaluate whether early and late side effects of radiotherapy can be predicted by the assay, a study was conducted of the association between the results of in vitro radiosensitivity tests and acute and late adverse radiation effects.METHODSIntrinsic molecular radiosensitivity was measured by using an initial radiation-induced DNA damage assay on lymphocytes obtained from breast cancer patients before radiotherapy. Acute reactions were assessed in 108 of these patients on the last treatment day. Late morbidity was assessed after 7 years of follow-up in some of these patients. The Radiation Therapy Oncology Group (RTOG) morbidity score system was used for both assessments.RESULTSRadiosensitivity values obtained using the in vitro test showed no relation with the acute or late adverse skin reactions observed. There was no evidence of a relation between acute and late normal tissue reactions assessed in the same patients. A positive relation was found between the treatment volume and both early and late side effects.CONCLUSIONAfter radiation treatment, a number of cells containing major changes can have a long survival and disappear very slowly, becoming a chronic focus of immunological system stimulation. This stimulation can produce, in a stochastic manner, late radiation-related adverse effects of varying severity. Further research is warranted to identify the major determinants of normal tissue radiation response to make it possible to individualize treatments and improve the outcome of radiotherapy in cancer patients.
PB BioMed Central
SN 1465-5411
YR 2005
FD 2005-07-01
LK http://hdl.handle.net/10668/636
UL http://hdl.handle.net/10668/636
LA en
NO López E, Guerrero R, Núñez MI, Moral R , Villalobos M , Martínez-Galán J et al. Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes. Breast Cancer Res. 2005;7(5):R690-8. Epub 2005 Jul 1.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 11, 2025