RT Journal Article
T1 Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle.
A1 Gómez-González, Belén
A1 Barroso, Sonia
A1 Herrera-Moyano, Emilia
A1 Aguilera, Andrés
K1 DNA damage response
K1 DNA-RNA hybrids
K1 genetic instability
K1 postreplication repair
K1 replicative stress
AB A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.
YR 2020
FD 2020-02-16
LK http://hdl.handle.net/10668/15116
UL http://hdl.handle.net/10668/15116
LA en
DS RISalud
RD Apr 7, 2025